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ProteomicsComparative analysis of WT CBL and CBL 70Z interactomes.
Cbl (Casitas B-lineage lymphoma) is a prominent post-translational regulator of protein tyrosine kinases (PTKs) that targets activated receptors for ubiquitination-mediated degradation. However, mutations within its E3 ubiquitin ligase activity rendering RING domain are often not sufficient to induc...
ORGANISM(S): Homo sapiens (Human) 
2021-02-26 | PXD011369 | Pride
On-beads digestion. Rtks Ubiquitination Cbl Label-free quantitation Endosomal trafficking 
TranscriptomicsTracing the development of acute myeloid leukemia in CBL-syndrome
Comparison of copy number variations of acute myeloid leukemia mononuclear cells and the given cell types collected during complete remission of the acute myeloid leukemia
ORGANISM(S): Homo sapiens 
2014-02-12 | E-MEXP-3997 | biostudies-arrayexpress
ProteomicsLocking CBL in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukaemia (part2)
Casitas B-lineage lymphoma (CBL) is critical to the negative regulation of receptor protein tyrosine kinases (RTKs). Mutant CBL can act as an adaptor and gain function to cause myeloproliferative diseases. Currently, there is no beneficial treatment available for leukaemia patients with CBL mutation...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051179 | Pride
Peptide inhibitor cblock Leukaemia Cbl tyrosine kinase binding domain Casitas b-lineage lymphoma (cbl) 
ProteomicsAnalysis of the CBL and CBLB signalosomes in primary T cells
T-cell receptor (TCR) signaling is essential for the function of T cells and negatively regulated by the E3 ubiquitin-protein ligases CBL and CBLB. Here we combine mouse genetics and affinity purification coupled to quantitative mass spectrometry to monitor the dynamics of the CBL and CBLB signaling...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-14 | PXD004130 | Pride
Ap-ms Cblb Primary t cell Cbl Tcr Interactome Signalosome 
GenomicsQuantitative Analysis of Wild Type CBL, CBL 70Z and Y371S 3T3 Stable Cell Transcriptomes
Quantitative Analysis of Wild Type CBL, CBL 70Z and Y371S 3T3 Stable Cell Transcriptomes
PRJNA495948 | ENA
TranscriptomicsGenome wide transcriptional profiling of c-Cbl deficient hematopoietic stem and progenitor cells
Expression of genes that are differentially expressed between c-Cbl control and c-Cbl mutant hematopoietic stem and progenitor cells were identified through this approach. Interestingly, several leukemia associated genes, particularly transcription factors, were differentially expressed between c-Cb...
ORGANISM(S): Mus musculus 
2010-08-12 | E-GEOD-23564 | biostudies-arrayexpress
TranscriptomicsCbl family proteins are required to maintain the proteome homeostasis in mammary epithelial cells
EGFR degradation is delayed in Cbl, Cbl-b double-deficient MCF10A but EGF stimulation does not enhance their growth. We performed a transcriptome analysis to gain insights into biological consequences of Cbl, Cbl-b loss in mammary epithelial cells. We compared the transcriptome of MCF10A cells expre...
ORGANISM(S): Homo sapiens 
2016-03-25 | E-GEOD-67301 | biostudies-arrayexpress
TranscriptomicsSNP chip data of MDS
Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic progenitors characterized by ineffective hematopoiesis and high propensity to leukemias. Although a number of gene targets have been identified, in many MDS cases, particular genetic targets are unknown. In this study, we performe...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-15187 | biostudies-arrayexpress
Proteomicsin vitro ubiquitination by E3 ligase Cbl-b
Fungal infections claim an estimated 1.5 million lives every year. Mechanisms that protect from fungal infections are still elusive. Recognition of fungal pathogens relies on C-type lectin receptors (CLR) and their downstream signaling kinase SYK. Here we report that the E3-ubiquitin-ligase CBL-B co...
ORGANISM(S): Homo sapiens (Human) 
2016-06-17 | PXD004256 | Pride
Lc-ms Cbl-b Ubiquitin linkage 
GenomicsNext generation sequencing transcriptomic analysis of bone marrow derived macrophages within control, Cbl-/-, Cbl-b -/- and DKO genotypes
Next generation sequencing transcriptomic analysis of bone marrow derived macrophages within control, Cbl-/-, Cbl-b -/- and DKO genotypes
PRJNA540522 | ENA
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