Sort   by:  
 Page size 
Proteomicsin vitro ubiquitination by E3 ligase Cbl-b
Fungal infections claim an estimated 1.5 million lives every year. Mechanisms that protect from fungal infections are still elusive. Recognition of fungal pathogens relies on C-type lectin receptors (CLR) and their downstream signaling kinase SYK. Here we report that the E3-ubiquitin-ligase CBL-B co...
ORGANISM(S): Homo sapiens (Human) 
2016-06-17 | PXD004256 | Pride
Lc-ms Cbl-b Ubiquitin linkage 
GenomicsNext generation sequencing transcriptomic analysis of bone marrow derived macrophages within control, Cbl-/-, Cbl-b -/- and DKO genotypes
Next generation sequencing transcriptomic analysis of bone marrow derived macrophages within control, Cbl-/-, Cbl-b -/- and DKO genotypes
PRJNA540522 | ENA
GenomicsGerminal Center B cells RNA-Seq (WT and Cbl-/-Cblb-/-)
Germinal Center B cells RNA-Seq (WT and Cbl-/-Cblb-/-)
PRJNA434305 | ENA
ProteomicsProteomics of late signaling responses decipher the roles of Cbl and Cbl-b in neuroblastoma cell differentiation
We applied quantitative mass spectrometry (MS)-based proteomics to study the roles of Cbl and Cbl-b in long-term signaling responses related to neurite outgrowth and differentiation of SH-SY5Y neuroblastoma cells. Using stable isotope labeling by amino acids in cell culture (SILAC) and tandem mass t...
ORGANISM(S): Homo sapiens (Human) 
2021-03-30 | PXD020389 | Pride
Human Lc-msms Neuroblastoma Cbl Cblb 
Proteomicsin vitro ubiquitination by E3 ligase Cbl-b
Fungal infections claim an estimated 1.5 million lives every year. Mechanisms that protect from fungal infections are still elusive. Recognition of fungal pathogens relies on C-type lectin receptors (CLR) and their downstream signaling kinase SYK. Here we report that the E3-ubiquitin-ligase CBL-B co...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080745 | MassIVE
TranscriptomicsNext generation sequencing transcriptomic analysis of bone marrow derived macrophages within control, Cbl-/-, Cbl-b -/- and DKO genotypes
The goal of the transcriptomic profiling is to understand what genes or pathway Cbl and Cbl-b regulate for CSF-1R dependent growth signaling
ORGANISM(S): Mus musculus 
2019-05-01 | GSE130527 | GEO
GenomicsSomatic deficiency of human CBL in leukocytes impairs B cell but not T cell development and function
Somatic deficiency of human CBL in leukocytes impairs B cell but not T cell development and function
PRJNA1327862 | ENA
TranscriptomicsSomatic deficiency of human CBL in leukocytes impairs B cell but not T cell development and function
The casitas B lineage lymphoma (CBL) proto-oncogene promotes positive selection and antigen responses in murine T lymphocytes by ubiquitinating ZAP70. However, CBL and CBL-B are redundant for ubiquitination of SYK and regulation of B cell receptor (BCR) signaling in murine B cells. We studied lympho...
ORGANISM(S): Homo sapiens 
2025-12-01 | GSE307942 | GEO
UnknownA novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells.
Not available
S-EPMC5239462 | biostudies-literature
GenomicsCBL and CBL-B Restrain Tfh Cell Responses and Systemic Lupus Erythematosus by Facilitating BCL-6 Degradation via the Chaperone-Mediated Autophagy
CBL and CBL-B Restrain Tfh Cell Responses and Systemic Lupus Erythematosus by Facilitating BCL-6 Degradation via the Chaperone-Mediated Autophagy
PRJNA988126 | ENA
Sort   by:  
 Page size