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TranscriptomicsDrosophila COP9 Signalosome Subunit 7 interacts with multiple genomic loci
The COP9 signalosome protein complex has a central role in the regulation of development of multi-cellular organisms. While the function of this complex in ubiquitin-mediated protein degradation is well established, results over the past few years have hinted that the COP9 signalosome may function m...
ORGANISM(S): Drosophila melanogaster 
2014-09-22 | E-GEOD-61605 | biostudies-arrayexpress
TranscriptomicsPost-transcriptional fine-tuning of COP9 signalosome subunit biosynthesis is regulated by the c-Myc/Lin28B/let-7 pathway
The COP9 signalosome (CSN) is a conserved protein complex occurring in all eukaryotes. The mammalian CSN consists of eight subunits (CSN1 – CSN8) and possesses an intrinsic metalloprotease JAMM motif localised to CSN5. In addition, it is associated with kinases such as protein kinase CK2 and D and t...
ORGANISM(S): Homo sapiens 
2011-10-26 | E-GEOD-19085 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis csn3-1, csn4-1 and csn5 (csn5a-2 csn5b) COP9 signalosome (csn) mutant analysis
Transcript profiling analysis of csn3-1, csn4-1 and csn5 (csn5a-2 csn5b) light grown and dark grown mutant seedlings compared to light grown and dark grown wild type using Arabidopsis ATH1 GeneChip array Experiment Overall Design: We compare eight samples of 7 day-old light grown or dark grown csn3-...
ORGANISM(S): Arabidopsis thaliana 
2008-06-16 | E-GEOD-9728 | biostudies-arrayexpress
TranscriptomicsRole of CSN5 in breast cancer (siRNA transfections)
CSN5 has been implicated as a candidate oncogene in human breast cancers by genetic linkage with activation of the poor-prognosis, wound response gene expression signature. CSN5 is a subunit of the eight-protein COP9 signalosome, a signaling complex with multiple biochemical activities; the mechanis...
ORGANISM(S): Homo sapiens 
2010-06-29 | E-GEOD-9204 | biostudies-arrayexpress
TranscriptomicsRole of CSN5 in breast cancer (array CGH)
CSN5 has been implicated as a candidate oncogene in human breast cancers by genetic linkage with activation of the poor-prognosis, wound response gene expression signature. CSN5 is a subunit of the eight-protein COP9 signalosome, a signaling complex with multiple biochemical activities; the mechanis...
ORGANISM(S): Homo sapiens 
2010-06-29 | E-GEOD-9205 | biostudies-arrayexpress
TranscriptomicsRole of CSN5 in breast cancer
CSN5 has been implicated as a candidate oncogene in human breast cancers by genetic linkage with activation of the poor-prognosis, wound response gene expression signature. CSN5 is a subunit of the eight-protein COP9 signalosome, a signaling complex with multiple biochemical activities; the mechanis...
ORGANISM(S): Homo sapiens 
2010-06-29 | E-GEOD-9206 | biostudies-arrayexpress
TranscriptomicsThe COP9 signalosome mediates transcriptional and metabolic response during fungal development
The COP9 signalosome complex (CSN) is a crucial regulator of ubiquitin ligases. Defects in CSN result in embryonic impairment and death in higher eukaryotes, whereas the filamentous fungus Aspergillus nidulans survives without CSN, but is unable to complete sexual development. We investigated overal...
ORGANISM(S): Emericella nidulans 
2010-09-09 | E-GEOD-22442 | biostudies-arrayexpress
GenomicsDrosophila COP9 Signalosome Subunit 7 interacts with multiple genomic loci
The COP9 signalosome protein complex has a central role in the regulation of development of multi-cellular organisms. While the function of this complex in ubiquitin-mediated protein degradation is well established, results over the past few years have hinted that the COP9 signalosome may function m...
ORGANISM(S): Drosophila melanogaster 
2014-09-22 | GSE61605 | GEO
TranscriptomicsExpression profile of ypr045cM-bM-^HM-^F mutant
We report a new protein complex with a role in transcription elongation that is formed by Ypr045c (Thp3) and the Csn12 component of the COP9-signalosome. Thp3-Csn12 is recruited to transcribed genes. Their mutations suppress the gene expression defects of mutants of the THO complex involved in mRNP ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-02-23 | E-GEOD-18994 | biostudies-arrayexpress
ProteomicsThe COP9 signalosome reduces neuroinflammation and attenuates ischemic neuronal stress in organotypic brain slice culture model
In the context of studying the role of the COP9 signalosome (CSN) in neuroinflammation and ischemic neuronal damage, we studied the effect of the cullin NEDDylation state-modifying drugs MLN4924 and CSN5i-3 in BV2 microglial cells, an immortalized murine cell line featuring many of the characteristi...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD044650 | Pride
Constitutive photomorphogenesis 9 signalosome (csn) Ischemic stroke Jab1 Csn5 Microglia Organoid 
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