Malt1 - OmicsDI

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Coumaphos syn-dimer (1)
(2S,3R,4R,5S,6S)-6-[(2R,3R,4R,5R,6R)-3-acetamido-2-hydroxy-6-(hydroxymethyl)-5-sulfonatooxyoxan-4-yl]oxy-3,4-dihydroxy-5-sulfonatooxyoxane-2-carboxylate (1)
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Methyl (1R,4aS,6aR,6aS,6bR,8aR,10S,11R,12aR,14bS)-10,11-dihydroxy-1,6a,6b,9,9,12a-hexamethyl-2-methylidene-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate (1)
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Jnj-42041935 (1)
6-{3-[6-(3,4-dihydroxy-6-methyl-5-oxooxan-2-yl)-5,7-dihydroxy-4-oxo-4H-chromen-2-yl]phenoxy}-3,4,5-trihydroxyoxane-2-carboxylic acid (1)
[5-[5,7-Dihydroxy-6-[4-hydroxy-6-methyl-5-oxo-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]-4-oxochromen-2-yl]-2-hydroxyphenyl] hydrogen sulate (1)
6-{5-[6-(3,4-dihydroxyphenyl)-8,13-dihydroxy-4-oxo-3,11-dioxatricyclo[8.4.0.0(2),]tetradeca-1(10),2(7),8-trien-12-yl]-2-hydroxyphenoxy}-3,4,5-trihydroxyoxane-2-carboxylic acid (1)
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6-{[5,7-dihydroxy-4-oxo-2-phenyl-8-(3,4,5-trihydroxyoxan-2-yl)-4H-chromen-6-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid (1)
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5,7-dihydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-8-(3,4,5-trihydroxyoxan-2-yl)-2-(2,4,5-trihydroxyphenyl)-4H-chromen-4-one (1)
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Lab affiliation

Team SOAP, CRCI2NA, Nantes Université, Inserm, CNRS, Université d’Angers, Nantes, France (2)
Pears Chair of Molecular Immunology Institute of Immunity & Transplantation The Pears Building - Royal Free Hospital University College London (2)
Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL, 32610, USA. (1)
University of British Columbia - Center for blood research (1)
Department of Proteomics and Signal Transduction Max Planck Institute of Biochemistry Germany (1)
Center for blood research, University of British Columbia,Vancouver BC, Canada (1)

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A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [Spleen dataset]

Attempts at modeling chromosomal translocations involving MALT1 gene, hallmarks of human mucosa-associated lymphoid tissue (MALT) lymphoma, have failed to reproduce the disease in mice. Here we describe a transgenic model in which MALT1 expression was targeted to mouse hematopoietic stem/progenitor ...

ORGANISM(S): Mus musculus

2012-07-09 | E-GEOD-25637 | biostudies-arrayexpress

A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma

This SuperSeries is composed of the following subset Series: GSE25636: A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [MouseSca1 dataset] GSE25637: A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human m...

ORGANISM(S): Mus musculus

2012-07-09 | E-GEOD-25639 | biostudies-arrayexpress

Gene expression profiling of rat jejunum treated with MLT-943, a small molecule MALT1 protease inhibitor

MALT1 protease inhibition is effective in several preclinical models of autoimmunity and B cell malignancies. However, severe reduction in regulatory T cells (Tregs) and an associated IPEX-like pathology was observed in mice with congenital deficiency of MALT1. Rats treated with MLT-943, a novel pot...

ORGANISM(S): Rattus norvegicus

2020-04-30 | E-MTAB-8990 | biostudies-arrayexpress

A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [MouseSca1 dataset]

ORGANISM(S): Mus musculus

2012-07-09 | E-GEOD-25636 | biostudies-arrayexpress

A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [MALT dataset]

ORGANISM(S): Homo sapiens

2012-07-09 | E-GEOD-25638 | biostudies-arrayexpress

Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma

A key element for the development of suitable anti-cancer drugs is the identification of cancer-specific enzymatic activities that can be therapeutically targeted. Mucosa-associated lymphoid tissue transformation protein 1 (MALT1) is a proto-oncogene that contributes to tumorigenesis in diffuse larg...

ORGANISM(S): Homo sapiens

2012-09-20 | E-GEOD-41034 | biostudies-arrayexpress

Expression of MALT1 oncogene in mouse hematopoietic stem/progenitor cells recapitulates the pathogenesis of human MALT lymphoma

Comparison of gene expression profiling analysis of bone marrow isolated CD34+ cells from patients with MALT lymphoma vs. healthy individuals revealed a large number of differentially expressed genes that included NF-kB target genes, genes involved in inflamatory signalling and immunoglobulin genes,...

ORGANISM(S): Homo sapiens

2012-07-09 | E-GEOD-34015 | biostudies-arrayexpress

MALT1 paracaspase controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping

Glioblastoma stem-like cells (GSCs) compose a tumor-initiating and propagating-population, remarkably vulnerable to any variation in the stability and integrity of the endolysomal compartment. Previous work showed that the expression and activity of the paracaspase MALT1 control GSC viability via ly...

ORGANISM(S): Homo sapiens (Human)

2025-01-16 | PXD040855 | Pride

MALT1 paracaspase controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping

ORGANISM(S): Homo sapiens (Human)

2025-01-16 | PXD040862 | Pride

Malt1 Srebp2 Niemann-pick type c1 Lysoip Glioblastoma Lysosomes Cholesterol

TMT10-TAILS for monitoring MALT1 substrate cleavage

We used TMT-TAILS to monitor MALT1 substrate cleavage in normal EBV B lymphocytes stimulated with PMA/ionomycin to evaluate kinetic profiles of MALT1 inhibitors

ORGANISM(S): Homo sapiens (Human)

2018-10-02 | PXD008421 | Pride

Malt1 Lymphocyte N-terminomics

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