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ProteomicsProteomic analysis of LysoIP from HeLa untagged, Control and ASAH1-/-
This quantitative proteomic analysis of lysosome-enriched fractions isolated by immunoprecipitation (LysoIP) from HeLa cells expressing TMEM192-3xHA, untagged controls, and ASAH1 knockout lines. Triplicate biological replicates were processed using TMTpro 18-plex labeling and high-resolution Orbitra...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD067219 | Pride
Lysoip Pd In Ida Lysosome dysfunction Neurodegeneration Tmtpro 
UnknownTagless LysoIP for immunoaffinity enrichment of native lysosomes from clinical samples.
Not available
S-EPMC11827837 | biostudies-literature
ProteomicsTagless LysoIP method for molecular profiling of lysosomal content in clinical samples
Lysosomes are implicated in a wide spectrum of human diseases including monogenic lysosomal storage disorders (LSDs), age-associated neurodegeneration and cancer. Profiling lysosomal content using tag-based lysosomal immunopurification (LysoIP) in cell and animal models allowed major discoveries in ...
ORGANISM(S): Homo sapiens (Human) 
2025-01-31 | PXD052082 | Pride
Metabolomics Proteomics Dia Lysosomal storage disorder Lipidomics Lysosome Mass spectrometry 
ProteomicsLysoIP-based lysosomal proteomic analysis of WT and mucolipidosis II mouse fibroblasts
This project contains LC–MS/MS-based LysoIP proteomic data from wild-type and mucolipidosis II mouse fibroblasts. The dataset supports the analysis of lysosomal proteome remodeling in a Gnptab p.R364X knock-in mouse model of mucolipidosis II.
ORGANISM(S): Mus Musculus 
2026-05-28 | PXD078968 |
ProteomicsMALT1 paracaspase controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping
Glioblastoma stem-like cells (GSCs) compose a tumor-initiating and propagating-population, remarkably vulnerable to any variation in the stability and integrity of the endolysomal compartment. Previous work showed that the expression and activity of the paracaspase MALT1 control GSC viability via ly...
ORGANISM(S): Homo sapiens (Human) 
2025-01-16 | PXD040855 | Pride
Malt1 Srebp2 Niemann-pick type c1 Lysoip Glioblastoma Lysosomes Cholesterol 
ProteomicsCell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associated Disease as a Lysosomal Disorder
LysoIP experiment using Fcrls-2A-Cre (Microglia) mouse line to characterize the lysosomal content, in addition to MSV000096018 deposit.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-06-19 | MSV000098265 | MassIVE
ProteomicsThe Batten disease gene product CLN3 is required for the efflux of glycerophosphodiesters from lysosomes
The lysosome has many cellular roles, including degrading and recycling macromolecules and signaling to the mTORC1 growth regulator. Lysosomal dysfunction occurs in various human diseases, including common neurodegenerative diseases as well as monogenic lysosomal storage disorders (LSDs). For most L...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-11 | PXD018624 | Pride
Batten disease Liver Mouse Cln3 Lysosome 
ProteomicsLysosomal protein atlas of brain cell types identifies SLC45A1-associated disease as a lysosomal disorder
LysoIP experiment using different Cre-lines to characterize the lysosomal content of the brain. Using Syn1-Cre (Neurons), Gfap-Cre (Astrocytes), Olig2-Cre (Oligodendrocytes) and Cx3cr1-Cre (Microglia) mouse lines, to understand by MS the different composition.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-10-03 | MSV000096018 | MassIVE
ProteomicsLysosomal proteomics reveals mechanisms of neuronal apoE4 - 2 associated lysosomal dysfunction
The E4 variant of APOE is the primary risk factor for Alzheimer’s Disease. While APOE is primarily expressed by astrocytes, early AD pathology appears predominantly in neurons, including endosomal abnormalities and mitochondrial dysfunction. Lysosomes are poised at the convergence point between thes...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD044942 | Pride
Lgals3bp Apms Mass spectrometry Apoe 4 Alzheimer’s disease Lysosomes 
ProteomicsMultiomic Approach Characterises the Neuroprotective Role of Retromer in Regulating Lysosomal Health
Retromer controls cellular homeostasis through regulating integral membrane protein sorting and transport and by controlling late-stage maturation of the endo-lysosomal network. Retromer dysfunction, which is linked to neurodegenerative disorders including Parkinson’s and Alzheimer’s diseases, manif...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD041323 | Pride
Human Lysoip Neuroglioma Whole cell proteome H4 Retromer Secretome Cell surface proteome Lc-ms/ms 
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