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ProteomicsQuantitative proteomics analysis of the Arg/N-end rule pathway of targeted degradation in Arabidopsis roots
According to the Arg/N-end rule pathway, proteins with basic N-termini are targeted for degradation by the Arabidopsis thaliana E3 ligase, PROTEOLYSIS6 (PRT6). Proteins can also become PRT6 substrates following post-translational arginylation by arginyltransferases ATE1 and 2. Here, we undertook a q...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2015-03-26 | PXD001719 | Pride
Tmt N-end rule Root Tails Quantitative proteomics 
ProteomicsQuantitative N-terminome of N-end rule mutant in Arabidopsis
According to the /N-end rule pathway, proteins with basic N-termini are targeted for degradation by the Arabidopsis thaliana E3 ligase, PROTEOLYSIS6 (PRT6). Here, we undertook a quantitative proteomics study of N-end rule mutant prt6, to investigate the impact of this pathway on the etiolated seedli...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2017-10-27 | PXD006450 | Pride
N-terminome Arabidopsis N-end rule mutant etiolated seedlings tmt- labelling tails 
ProteomicsTMT10-TAILS for monitoring MALT1 substrate cleavage
We used TMT-TAILS to monitor MALT1 substrate cleavage in normal EBV B lymphocytes stimulated with PMA/ionomycin to evaluate kinetic profiles of MALT1 inhibitors
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD008421 | Pride
Malt1 Lymphocyte N-terminomics 
ProteomicsTMT10-TAILS for monitoring MALT1 substrate cleavage
We used TMT-TAILS to monitor MALT1 substrate cleavage in normal EBV B lymphocytes stimulated with PMA/ionomycin to evaluate kinetic profiles of MALT1 inhibitors
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-10-11 | MSV000083026 | MassIVE
UnknownN-terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N-end rule pathway.
Not available
S-EPMC5947142 | biostudies-literature
ProteomicsSystemic toxicity of snake venom metalloproteinases: proteomics analyses of kidney injury and blood plasma disturbances in a mouse model
Metalloproteinases are abundant in viperid venoms and are implicated in several envenomation effects. Bothrops jararaca venom is reported to induce kidney injury and coagulopathy. HF3 is an extremely hemorrhagic metalloproteinase from B. jararaca venom and participates in the local pathogenesis of e...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-01-20 | MSV000091101 | MassIVE
ProteomicsN-terminomics on WT and CASP2 KO mouse hearts
To identify putative substrates processed by Caspase-2 in response to PIDDosome activation in cardiomyocytes, we performed N-terminomics by TMT10-TAILS on P7 hearts isolated from XMLC2-Casp2fl/fl and XMLC2+Casp2fl/fl mice.
ORGANISM(S): Mus musculus (Mouse) 
2026-01-15 | PXD060421 | Pride
Tmt-tails Caspase 2 Heart developement N-terminomics 
UnknownGlobal analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture.
Not available
S-EPMC7116560 | biostudies-literature
ProteomicsFunctional insights into protein acetylation in the hyperthermophilic archaeon Sulfolobus islandicus
Proteins undergo acetylation at the Nε-amino group of lysine residues and the Nα-amino group of the N-terminus in Archaea as in Bacteria and Eukarya. However, the extent, pattern and roles of the modifications in Archaea remain poorly understood. Here we report the proteomic analyses of a wild-type ...
ORGANISM(S): Sulfolobus islandicus REY15A 
2019-06-12 | PXD012246 | Pride
Quantitative proteomics Protein acetylome Gene deletion Mutant phenotype N-terminal acetyltransferase Protein lysine acetyltransferase 
UnknownLoss of CEP70 function affects acrosome biogenesis and flagella formation during spermiogenesis.
Not available
S-EPMC8116340 | biostudies-literature
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