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UnknownA heptad repeat in herpes simplex virus 1 gH, located downstream of the alpha-helix with attributes of a fusion peptide, is critical for virus entry and fusion.
Not available
S-EPMC1112143 | biostudies-literature
TranscriptomicsGEP signatures in tumors from women with high grade early breast cancer
Several molecular signatures are able to predict the activity of adjuvant chemotherapy in breast cancer patients. However, no molecular data are already available to detect microenvironment molecular signature that can identify patients who are good candidates for treatment with immune checkpoint in...
ORGANISM(S): Homo sapiens 
2020-12-23 | GSE147472 | GEO
TranscriptomicsRole of Apollon in human melanoma resistance to anti-tumor agents that activate the intrinsic or the extrinsic apoptosis pathways
PURPOSE: To assess the role of Apollon in melanoma resistance to intrinsic and extrinsic pathways of apoptosis and to identify strategies to reduce its expression. EXPERIMENTAL DESIGN: Expression of Apollon was assessed in melanoma cell lines and in surgical specimens.Gene expression profiling, m...
ORGANISM(S): Homo sapiens 
2012-07-10 | E-GEOD-34686 | biostudies-arrayexpress
UnknownFeasibility and cardiac safety of trastuzumab emtansine after anthracycline-based chemotherapy as (neo)adjuvant therapy for human epidermal growth factor receptor 2-positive early-stage breast cancer.
Not available
S-EPMC5657012 | biostudies-literature
TranscriptomicsGene expression analysis of Hodgkin lymphoma cell lines treated with the AKT inhibitor perifosine and the multikinase inhibitor sorafenib
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-01-29 | E-GEOD-31060 | biostudies-arrayexpress
UnknownDevelopment and validation of a GC × GC-ToFMS method for the quantification of pesticides in environmental waters.
Not available
S-EPMC10328859 | biostudies-literature
TranscriptomicsSynergistic anti-tumor activity by association of MEK and PI3K/mTOR blockade with TRAIL in human melanoma
Combining direct anti-tumor effects with targeting of tumor microenvironment is an attractive strategy that may lead to more effective therapies for advanced melanoma. Here, we tested whether association of TRAIL with co-targeting of MEK and PI3K/mTOR, or with MEK blockade, could have synergistic a...
ORGANISM(S): Homo sapiens 
2014-10-08 | E-GEOD-55050 | biostudies-arrayexpress
TranscriptomicsStudies on the production of fungal polyketides in Aspergillus nidulans using systems biology tools
Using genetic engineering tools available for the model organism Aspergillus nidulans, we constructed two recombinant strains; one expressing the model polyketide Penicillium griseofulvum 6-methylsalicylic acid (6-MSA) polyketide synthase gene, and one expressing the 6-MSA gene and overexpressing th...
ORGANISM(S): Emericella nidulans 
2009-02-27 | E-GEOD-12859 | biostudies-arrayexpress
ProteomicsS100A3 binds directly to RARα and the PML-RARα onco-protein modulating their stability and activit
We defined the RARα interactome in the MDA-MB453 breast cancer cell line genetically engineered to over-express an N-terminally tagged version of the nuclear retinoic acid receptor. Twenty eight nuclear proteins which interact with RARα and whose interaction is stimulated or reduced by the pan-RAR ...
ORGANISM(S): Homo sapiens (Human) 
2019-12-18 | PXD008761 | Pride
Raralpha Silac Interactome 
TranscriptomicsAnalysis of Gene expression of human Th17 and Th1 clones
Human T cell clones were derived according to standard protocols using different mix of cytokines, once assessed for their functional profile were studied for gene expression. The purpose of this study is to analyze human Th1 and Th17 clones with and without stimulation with PMA and Ionomycin to mea...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-30664 | biostudies-arrayexpress
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