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Tenosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) are related conditions with features of both reactive inflammatory disorders and clonal neoplastic proliferations. Chromosomal translocations involving chromosome 1p13 have been reported in both TGCT and PVNS. We confir...
ORGANISM(S): Homo sapiens 
Single-cell RNA sequencing of human giant cell tumor of bone
Transcriptome profiling of three established giant cell tumour of bone (GCTB) cell lines on the BGISEQ-500 platform (PE100). Cell lines consist of neoplastic "stromal" cells harboring a heterozygous H3F3A p.G34W mutation. Data was used in a study (Venneker et al., Histone deacetylase inhibitors as a...
Single cell sequencing reveals the immunosuppressive trajectory in the tumor microenvironment of human giant cell tumor of bone
Characterizing the tumor microenvironment at the single-cell level reveals the potential immune evasion mechanism in giant cell tumor of bone
Spatial analysis revealed localization of osteblastogenesis-inhibitory factors in Giant Cell Tumor of Bone
Patient-derived bone tumor (osteosarcoma and giant cell tumor of bone) cells, and the normal mesenchymal stem cells and osteoblasts were cultured and subjected to UV crosslinking (UV) at 254 nm or without crosslinking (noUV) as negative controls. Subsequently, RNA-binding proteins (RBPs) were identi...
ORGANISM(S): Homo sapiens (Human) 
2024-02-28 | PXD038185 | Pride
Gene expression profile of human osteoclastoma bone tumor derived giant osteoclast cells
Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. The purpose of the present study was to identify GBM cell-selective secreted proteins by analyzing conditioned media (CM) from GBM, breast, and colon cancer cell lines using sequential window acquisition of all theoretical s...
ORGANISM(S): Homo Sapiens (human) 
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