Sort   by:  
 Page size 
TranscriptomicsGene expression profiling by DNA microarray in Colo741 cell line transfected by KRas-G12D or KRas-G12V
Mutations of the proto-oncogene KRas, together with the inactivation of the onco-suppressor genes APC and TP53, are considered to have an important role both in the carcinogenesis and in the colorectal tumor progression. The oncogene K-ras has activating mutations, especially in codon 12, in about ...
ORGANISM(S): Homo sapiens 
2008-12-17 | E-GEOD-12398 | biostudies-arrayexpress
TranscriptomicsChromosomal aberrations and aneuploidy in oral potentially malignant lesions: distinctive features for tongue.
The mucosae of the oral cavity are different at the histological level but are all exposed to common genotoxic agents. As a result of this exposure, changes in the mucosal epithelia develop giving rise to Oral Potentially Malignant Lesions (OPMLs), which with time may in turn progress to Oral Squamo...
ORGANISM(S): Homo sapiens 
2011-10-19 | E-GEOD-28868 | biostudies-arrayexpress
TranscriptomicsGenomic aberrations in distant fields from oral potentially malignant lesions by high resolution DNA flow cytometry and array-CGH
The aim of the study was to address the concept of field cancerization in oral cancer. The presence of genomic aberrations, indicative of chromosomal instability (CIN), in oral distant fields (ODFs) of visually normal and non-dysplastic mucosa at the mirror image from concomitant oral potentially ma...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-28906 | biostudies-arrayexpress
TranscriptomicsNAC, Tiron and Trolox impair GBM tumorigenic cell survival by mechanisms independent from antioxidant activity
The aim of this study is to determine if, using antioxidant drugs, it is possible to interfere with the proliferative capabilities of the human glioblastoma (GBM) tumor-initiating cells (TICs). To establish which cellular processes are activated in GBM TICs by the antioxidants NAC, Tiron and Trolox,...
ORGANISM(S): Homo sapiens 
2014-03-04 | E-GEOD-44099 | biostudies-arrayexpress
TranscriptomicsThe gamma secretase inhibitor LLNle induces apoptosis of human GBM tumor initiating cells
Glioblastomas (GBM) are poorly differentiated astrocytic tumors arising in the Central Nervous System (CNS), which despite aggressive treatments are still characterized by a fatal outcome. Several studies have shown the existence of a subpopulation of cells within glioma tumors displaying cancer ste...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14581 | biostudies-arrayexpress
TranscriptomicsGenomic DNA damage in oral potentially malignant disorders (OPMDs) and oral squamous cell carcinomas (OSCCs). Early detection of DNA aneuploidy and chromosomal aberrations in non dysplastic OPMDs.
Oral potentially malignant disorders (OPMDs) may precede oral squamous cell carcinoma (OSCC). Early detection of OPMDs has a crucial role in OSCC prevention. DNA aneuploidy and chromosomal aberrations are markers of genomic DNA damage and chromosomal instability (CIN), which is involved in cancer d...
ORGANISM(S): Homo sapiens 
2015-10-23 | E-GEOD-66136 | biostudies-arrayexpress
Sort   by:  
 Page size