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TranscriptomicsTranscriptional analysis of BCR-triggered immature and mature mouse B cells
The B cell antigen receptor (BCR) is a signaling complex that mediates differentiation stage-specific cell fate decisions in B lymphocytes. While several studies have evidenced differences in signal transduction components as being key to contrasting phenotypic outcomes, little is known about the di...
ORGANISM(S): Mus musculus 
2008-12-14 | E-GEOD-9215 | biostudies-arrayexpress
TranscriptomicsGene expression variation in lymphocyte subpopulations in response to low dose of ionizing radiations
Lymphocytes are the standard cell of a majority of biodosimetry approaches because of their availability and radiosensitivity. But progresses remain to be performed to bring down the minimum threshold of dose sensitivity. To find a lymphocyte subtype able to respond to low doses of ionizing radiatio...
ORGANISM(S): Homo sapiens 
2008-01-31 | E-GEOD-6978 | biostudies-arrayexpress
TranscriptomicsProstaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4
Recognition of foreign antigens by B cell receptor (BCR) on mature B cells leads to their clonal expansion, which is critically important for the effective host defence of the organism. However, excessive antigenic responses or reaction of B cells against body’s own components frequently lead to d...
ORGANISM(S): Mus musculus 
2008-12-14 | E-GEOD-9847 | biostudies-arrayexpress
TranscriptomicsGene array analysis of human CD34+ hematopoietic cells exposed during 24h to HOXB4 or HOXC4 homeoproteins
At the molecular level, the mechanisms of action of Hox genes during hematopoiesis remain elusive. Although reports have described the implication of Hox genes in some molecular pathways in mice, the targets of HOX proteins in human hematopoietic cells are mostly unidentified. Since HOXB4 and HOXC4 ...
ORGANISM(S): Homo sapiens 
2010-10-15 | E-GEOD-24379 | biostudies-arrayexpress
TranscriptomicsIdentification of new markers of cutaneous melanoma invasion
T1C3 is a clonal cell line from a human melanoma tumor, expressing PNA lectin, and characterized by a high capacity of dermal invasion. IC8 is a clonal cell line from a human melanoma tumor, negative for PNA lectin, and non-invasive. To identify new gene markers involved in the mechanisms of early i...
ORGANISM(S): Homo sapiens 
2010-12-15 | E-GEOD-15802 | biostudies-arrayexpress
TranscriptomicsCharacterisation of LAP/LIP transcriptional signature in human hepatoma cells
BACKGROUND & AIMS: C/EBPbeta is involved in numerous process as carcinogenesis but its role is still not clear due to the existence of an active form (LAP) and an inhibitory form (LIP) of this transcription factor. The main goals of the present research were (i) the identification of genes inversely...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-15010 | biostudies-arrayexpress
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