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UnknownStomach cancer risk after treatment for hodgkin lymphoma.
Not available
S-EPMC3770865 | biostudies-literature
ProteomicsUbiquitination in treated T. cruzi parasites
T. cruzi epimastigotes in the logarithmic growth phase (3×106 cells mL-1) were incubated for 12h with bortezomib (1.8 µM), GNF6702 (2.9 µM) or compound 1 (24 µM), equivalent to 8× the EC50 values of each compound. Controls were incubated in the presence of diluent (DMSO). Cells were harvested by cen...
ORGANISM(S): Trypanosoma cruzi Dm28c 
2022-02-17 | PXD027524 | Pride
Ubiquitination Trypanosoma cruzi Proteasome 
ProteomicsMultiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial
Samples were reduced by the addition of TCEP (25 mM final concentration) and incubated at 37 ºC for 10 min. Alkylation was carried out by the addition of iodoacetamide (25 mM final concentration) and incubated at RT for 1 h in the dark. Samples were then digested by the addition of 1:50 LysC (Wako, ...
ORGANISM(S): Leishmania donovani BPK282A1 
2021-07-18 | PXD023780 | Pride
Thermal proteome profiling Leishmania Oxidosqualene synthase 
UnknownEnhanced Delivery of Oncolytic Adenovirus by Neural Stem Cells for Treatment of Metastatic Ovarian Cancer.
Not available
S-EPMC6350263 | biostudies-literature
ProteomicsTarget deconvolution in Plasmodium falciparum using pulldowns
Parasite lysates were centrifuged (20,000 g, 4°C, 15 min). Beads (blank and with linker attached) were washed 3× with water then twice with lysis buffer. The lysate (~2 mg total protein) was first incubated with 2 mg blank beads for 30 min at 4°C with rotating agitation. The lysate was divided into ...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-10-15 | PXD033740 | Pride
Pulldown Plasmodium falciparum Drug target Chemical proteomics 
ProteomicsDrug target deconvolution in Plasmodium falciparum using thermal proteomics profiling
Early identification of a compound’s mode of action can greatly benefit the discovery process. Thermal proteomics profiling (TPP) is a powerful, unbiased tool that can be used to identify potential ligands of protein targets. TPP takes advantage of the fact that a ligand binding to its target prot...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-10-13 | PXD025182 | Pride
Lysine trna synthetase Thermal proteome profiling Plasmodium falciparum 
MetabolomicsHERPES SIMPLEX VIRUS TYPE 1 IMPAIRS DENDRITIC CELL FUNCTION BY REMODELLING NEUTRAL LIPID METABOLISM AND INDUCING LIPID DROPLET ACCUMULATION
Herpes simplex virus type 1 (HSV-1) infects dendritic cells (DCs), professional antigen-presenting cells that initiate and regulate host antiviral responses. HSV-1 infects DCs limiting their maturation, migration to draining lymph nodes and T cell activation capacity, ultimately promotes their apopt...
2025-04-03 | MTBLS5163 | MetaboLights
UnknownGDNF and Parkinson's Disease: Where Next? A Summary from a Recent Workshop.
Not available
S-EPMC7458523 | biostudies-literature
TranscriptomicsRNA-seq of WT and fkbp4 crispant Xenopus tadpoles
The airm of the approach was to identify genes in whole Xenopus tadpoles (Stage NF42) that are upregulated or downregulated due to disruption of the fkbp4 by CRISPR-Cas9 gene editing compared to control tadpoles. Xenopus fkbp4 crispants were generated to make a model of a novel human syndrome caused...
ORGANISM(S): Xenopus tropicalis 
2026-10-29 | E-MTAB-17717 | biostudies-arrayexpress
UnknownMachine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation.
Not available
S-EPMC5902191 | biostudies-literature
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