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UnknownChronic kidney disease, cerebral blood flow, and white matter volume in hypertensive adults.

Objective

To determine the relation between markers of kidney disease-estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (UACR)-with cerebral blood flow (CBF) and white matter volume (WMV) in hypertensive adults.

Methods

We used baseline data collected f...
S-EPMC4818564 | biostudies-literature
UnknownClinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study.

Introduction

The Cure Glomerulonephropathy Network (CureGN) is a 66-center longitudinal observational study of patients with biopsy-confirmed minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or IgA nephropathy (IgAN), including IgA vasculitis (IgAV). This s...
S-EPMC6224619 | biostudies-literature
UnknownEstimating and examining the costs of inpatient diabetes care in an Irish Public Hospital.

Aim

To estimate and examine hospitalisation costs of Type 1 and Type 2 diabetes in an Irish public hospital.

Methods

A retrospective audit of hospital inpatient admissions over a 5-year period was undertaken, and a wide range of admission-related data were collected for a sample of 7,...
S-EPMC9299992 | biostudies-literature
UnknownImpaired Redox and Protein Homeostasis as Risk Factors and Therapeutic Targets in Toxin-Induced Biliary Atresia.

Background & aims

Extrahepatic biliary atresia (BA) is a pediatric liver disease with no approved medical therapy. Recent studies using human samples and experimental modeling suggest that glutathione redox metabolism and heterogeneity play a role in disease pathogenesis. We sought to dissec...
S-EPMC7856536 | biostudies-literature
UnknownKidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure.

Rationale & objective

The safety of intensive blood pressure (BP) targets is controversial for persons with chronic kidney disease (CKD). We studied the effects of hypertension treatment on cerebral perfusion and structure in individuals with and without CKD.

Study design

Neuroimaging...
S-EPMC8926938 | biostudies-literature
UnknownDescriptive, Hospital-Based, 10-Year Study of Malaria Transmission in Goa, a Southwest Indian State in the Malaria Elimination Phase.
The South Asia International Center of Excellence for Malaria Research, an NIH-funded collaborative program, investigated the epidemiology of malaria in the Indian state of Goa through health facility-based data collected from the Goa Medical College and Hospital (GMC), the state's largest tertiary ...
S-EPMC11229636 | biostudies-literature
UnknownTargeted suppression of gibberellin biosynthetic genes ZmGA20ox3 and ZmGA20ox5 produces a short stature maize ideotype.
Maize is one of the world's most widely cultivated crops. As future demands for maize will continue to rise, fields will face ever more frequent and extreme weather patterns that directly affect crop productivity. Development of environmentally resilient crops with improved standability in the field...
S-EPMC9129074 | biostudies-literature
UnknownAn mRNA Vaccine against SARS-CoV-2 - Preliminary Report.

Background

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and spread globally, prompting an international effort to accelerate development of a vaccine. The candidate vaccine mRNA-1273 encodes the stabilized prefusion SARS-CoV-2 spike protein.

Method...

S-EPMC7377258 | biostudies-literature
UnknownViscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial.

Purpose

Contemporary trauma resuscitation prioritizes control of bleeding and uses major haemorrhage protocols (MHPs) to prevent and treat coagulopathy. We aimed to determine whether augmenting MHPs with Viscoelastic Haemostatic Assays (VHA) would improve outcomes compared to Conventional Co...
S-EPMC7550843 | biostudies-literature
UnknownYoung infants exhibit robust functional antibody responses and restrained IFN-γ production to SARS-CoV-2.
Severe COVID-19 appears rare in children. This is unexpected, especially in young infants, who are vulnerable to severe disease caused by other respiratory viruses. We evaluate convalescent immune responses in 4 infants under 3 months old with confirmed COVID-19 who presented with mild febrile illne...
S-EPMC8188298 | biostudies-literature
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