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ProteomicsProteomic analysis of human brain organoids
Microglia are specialised brain-resident macrophages that arise from primitive macrophages colonising the embryonic brain. Microglia contribute to multiple aspects of brain development, but their precise roles in early human brain remain poorly understood due to limited access to relevant tissues. T...
ORGANISM(S): Homo sapiens (Human) 
2025-11-26 | PXD044406 | Pride
Organoids Brain Quantitative proteome Microglia 
TranscriptomicsTissue-specific differentiation of a circulating CCR9- pDC-like common dendritic cell precursor
Committed precursors of conventional dendritic cells (pre-cDCs) derived from the common DC progenitor which differentiate into cDC subpopulations in peripheral tissues have been identified, but committed precursors for plasmacytoid DCs (pDCs) have not been found. Here we show that CDP-derived ‘CCR9-...
ORGANISM(S): Mus musculus 
2012-05-15 | E-GEOD-37996 | biostudies-arrayexpress
ProteomicsMicroglia and brain organoids
iPSC-derived microglia export cholesterol to neuronal cells in human brain organoids and promote their maturation
ORGANISM(S): Homo Sapiens (human) 
2023-05-19 | PXD042344 | JPOST Repository
TranscriptomicsTranscriptome profile of human dermal macrophages and monocyte-derived macrophages
DC, monocyte and macrophage networks are evolutionarily conserved but the distinct subsets have been difficult to distinguish due to shared overlapping phenotypic markers between the cells. Using transcriptome microarray profiling of human and mouse mononuclear phagocyte subsets, we have distinguish...
ORGANISM(S): Homo sapiens 
2014-10-15 | E-GEOD-60317 | biostudies-arrayexpress
TranscriptomicsHistone Methyltransferase Ezh2 Controls Cell Adhesion and Migration through Direct Methylation of the Extra-Nuclear Protein-Talin
Previously, we suggested a cytosolic role for the histone-methyltransferase Ezh2 in regulating lymphocyte activation, but molecular mechanisms underpinning this extra-nuclear function remained unclear. Here we show that Ezh2 regulates integrin-signaling and adhesion dynamics of neutrophils and dendr...
ORGANISM(S): Mus musculus 
2015-03-09 | E-GEOD-60146 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiles of mouse and human monocyte and dendritic cell subsets (human data)
Dendritic cells (DCs) are critical in mediating immunity to pathogens, vaccines, tumors and tolerance to self. Significant progress has been made in the study of DC subsets in murine models but the translation of these findings to human DC immunobiology has not been fully realized. Murine splenic C...
ORGANISM(S): Homo sapiens 
2012-07-11 | E-GEOD-35457 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiles of mouse and human monocyte and dendritic cell subsets (mouse data)
Dendritic cells (DCs) are critical in mediating immunity to pathogens, vaccines, tumors and tolerance to self. Significant progress has been made in the study of DC subsets in murine models but the translation of these findings to human DC immunobiology has not been fully realized. Murine splenic C...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-35458 | biostudies-arrayexpress
TranscriptomicsTranscriptome profile of mouse lung dendritic cell subsets and macrophages.
Dendritic cell (DC) are critical initiators and regulators of immunity to pathogens, vaccines, tumors and tolerance to self. Mouse and human dendritic cells (DCs) are comprised of functionally specialized subsets, but precise interspecies correlation is currently incomplete and hampers the full tra...
ORGANISM(S): Mus musculus 
2013-05-29 | E-GEOD-46680 | biostudies-arrayexpress
TranscriptomicsC-Myb+ erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages
Although classified as hematopoietic cells, tissue-resident macrophages are selfrenewing and maintained independently of adult hematopoiesis. While most macrophages originate from embryonic precursors that seed tissues prior to birth, their exact origin is unknown. Using an in utero macrophage deple...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-66970 | biostudies-arrayexpress
ProteomicsProteome profiling of an isogenic CAG allelic panel of Huntington disease hESCs and NPCs
Whole proteome profiling and quantification was performed on an isogenic Huntington disease (IsoHD) human embryonic stem cell (hESC) allelic panel. The IsoHD hESCs harbour 30, 45, 65 and 81 CAG repeats in the first exon of HTT. Whole proteome quantification was also performed on neural progenitor ce...
ORGANISM(S): Homo Sapiens (human) 
2019-02-14 | PXD006585 | JPOST Repository
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