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Comparison of human trabecular meshwork transcriptomes of cells glaucoma-linked MYOC mutant Q368X
ORGANISM(S): Homo sapiens 
Aim of this study was the evaluation of Alpha-crystallin B and its potential neuroprotective properties in an experimentalanimal model of glaucoma with subsequent analysis of possible altered downstream markers in a complex mass spectrometric approach.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2017-11-28 | MSV000081755 | MassIVE
A high percentage of vision loss and blindness worldwide are due to glaucoma and cataracts ocular diseases. Small extracellular vesicles (sEVs) are small lipidic vesicles involved in transport and cell-to-cell communication, released into different body fluids including eye’s aqueous humor. The iden...
ORGANISM(S): Homo sapiens (Human) 
2024-11-04 | PXD048815 | Pride
Comparison of human trabecular meshwork transcriptomes of cells overexpressing glaucoma-linked MYOC mutant R342K
ORGANISM(S): Homo sapiens 
Comparison of human trabecular meshwork transcriptomes of cells overexpressing glaucoma-linked MYOC mutant K423E
ORGANISM(S): Homo sapiens 
Comparison of human trabecular meshwork transcriptomes of cells overexpressing glaucoma-linked MYOC mutant D380N
ORGANISM(S): Homo sapiens 

Glaucoma results in vision loss due to damage of the optic nerve that is irreversible if undetected or untreated. The most common form of glaucoma is primary open angle glaucoma (POAG). While glaucoma affects all races, persons of African descent are disproportionately affected; studies show Afri...

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