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This experiment compared the expression of mRNAs and noncoding RNAs during neuronal-glial fate specification and oligodendrocyte lineage maturation. The primary aim of the experiment was to identify ncRNAs that were differentially expressed during this process.
ORGANISM(S): Mus musculus 
Single-cell Transcriptomics Resolves Intermediate Glial Progenitors and Uncovers a Pivotal Determinant of Cell Fate and Gliomagenesis
Glial progenitor cells comprise the most abundant population of progenitor cells in the adult human brain. They are responsible for CNS remyelination, and likely contribute to the astrogliotic response to brain injury and degeneration as well. Adult human GPCs are biased to differentiate as oligoden...
ORGANISM(S): Homo sapiens 
Evolution of the mammalian brain encompassed a remarkable increase in size of cerebral cortex, including tangential and radial expansion, but the mechanisms underlying these key parameters are still largely unknown. Here, we identified the novel DNA associated protein TRNP1 as a regulator of cerebra...
ORGANISM(S): Mus musculus 
The molecular basis of astrocyte differentiation and maturation is poorly understood. As microRNAs have important roles in cell fate transitions, we set out to study their function during the glial progenitor cell (GPC) to astrocyte transition. Inducible deletion of all canonical microRNAs in GPCs i...
ORGANISM(S): Mus musculus 
The mechanisms underlying the specification of oligodendrocyte fate from multipotent neural progenitor cells (NPCs) in developing human brain are unknown. In this study, we sought to identify antigens sufficient to distinguish NPCs free from oligodendrocyte progenitor cells (OPCs). We investigated t...
ORGANISM(S): Homo sapiens 
Neural stem cells (NSCs) generate neurons and glial cells throughout embryonic and postnatal brain development. The role of s-acylation, a reversible post-translational lipid modification of proteins, in regulating fate and activity of NSCs remains largely unknown. We here used an unbiased screening...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-27 | PXD014355 | Pride
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