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GenomicsGenome-wide mapping of CarD, RNAPs, and RNAPb on the Mycobacterium smegmatis genome using Chromatin Immunoprecipitation Sequencing
CarD is an essential mycobacterial protein that we had previously shown to bind the RNA polymerase (RNAP) and affect the transcriptional profile of M. smegmatis and Mycobacterium tuberculosis. For this reason, we suspected that CarD was directly regulating transcriptional complexes but we did not kn...
ORGANISM(S): Mycobacterium smegmatis 
2013-08-01 | E-GEOD-48164 | biostudies-arrayexpress
UnknownChalkophore mediated respiratory oxidase flexibility controls <i>M. tuberculosis</i> virulence.
Not available
S-EPMC11030325 | biostudies-literature
UnknownM.tuberculosis mutants lacking oxygenated mycolates show increased immunogenicity and protective efficacy as compared to M. bovis BCG vaccine in an experimental mouse model.
Not available
S-EPMC3798287 | biostudies-literature
TranscriptomicsMycobacterium smegmatis: I-SceI homing endonuclease generated genomic DNA damage in Darr strains expressing ArrWT, ArrH18A, ArrD83A, or an empty vector vs WT M. smegmatis Mc2155 (mgm182, site(+))
Transcriptional profiling of Mycobacterium smegmatis comparing strains undergoing I-SceI generated DNA damage at a single genomic locus Gene designations are the updated annotation Four comparisons were made, all with log phase cultures and no ATc added. Darr Site(+) with an empty vector compared to...
ORGANISM(S): Mycobacterium smegmatis 
2011-07-14 | E-GEOD-30635 | biostudies-arrayexpress
UnknownIntegrated sensing of host stresses by inhibition of a cytoplasmic two-component system controls M. tuberculosis acute lung infection.
Not available
S-EPMC8131098 | biostudies-literature
UnknownRecF and RecR Play Critical Roles in the Homologous Recombination and Single-Strand Annealing Pathways of Mycobacteria.
Not available
S-EPMC4560283 | biostudies-literature
UnknownHuman iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in <i>M. tuberculosis</i> host defense.
Not available
S-EPMC12330731 | biostudies-literature
UnknownA gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo.
Not available
S-EPMC3098235 | biostudies-literature
TranscriptomicsMycobacterium smegmatis: CarD depletion (mgm1703) vs Control (mgm1701)
Transcriptional profiling of Mycobacterium smegmatis comparing the effects of wild type levels of CarD expression with CarD depletion. Transcriptional profile of the mgm1701 control strain was compared with that of mgm1703, a strain where CarD transcription is regulated by a Tet-On system. Both stra...
ORGANISM(S): Mycobacterium smegmatis 
2010-05-16 | E-GEOD-15437 | biostudies-arrayexpress
UnknownMycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis.
Not available
S-EPMC2731493 | biostudies-literature
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