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ProteomicsIdentification of RIOK2 as a master regulator of human blood cell development
Myelodysplastic syndromes (MDS) are a group of hematologic neoplasms in which the bone marrow fails to produce enough mature blood cells, leading to peripheral blood cytopenias and myeloproliferation1-3. The average survival time following diagnosis of MDS is 2.5 years4, owing to few treatment optio...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-16 | MSV000088238 | MassIVE
TranscriptomicsThe transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism
Here we report that the transcription factor cyclic AMP–responsive element–binding protein H (CREB-H, encoded by CREB3L3) is required for the maintenance of normal plasma triglyceride concentrations. CREB-H–deficient mice showed hypertriglyceridemia secondary to inefficient triglyceride clearance ca...
ORGANISM(S): Mus musculus 
2011-06-04 | E-GEOD-29643 | biostudies-arrayexpress
TranscriptomicsAnalysis of wildtype and Xbp1-deficient hematopoietic progenitor cell transcriptomes
Purpose: The goals of this study are to assess the transcriptional networks governed by the transcription factor XBP1 in lineage-uncommitted myeloid progenitors and in eosinophil-committed myeloid progenitors. Methods: mRNA profiles of FACS-purified granulocyte-macrophage progenitors (GMPs) from X...
ORGANISM(S): Mus musculus 
2015-07-06 | E-GEOD-65753 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cell differentiation following treatment with DKK1
Assessed effect of DKK1 treatment on gene expression during the first four days of ES cell differentiation in serum containing medium.
ORGANISM(S): Mus musculus 
2006-12-31 | E-MEXP-759 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of XBP1-deficient ovarian cancer-associated dendritic cells (DCs)
ID8-based ovarian tumors were developed for 3 weeks in wild type (WT, N=3) or conditional knockout mice selectively deleting XBP1 in CD11c positive cells (KO, N=3). Tumor-associated DCs were independently sorted via FACS and used for transcriptional profiling. Total RNA from sorted tumor-associated ...
ORGANISM(S): Mus musculus 
2015-06-11 | E-GEOD-68472 | biostudies-arrayexpress
GenomicsGenome-wide maps of XBP1 binding sites in different breast cancer cell lines [ChIP-Seq]
We report the application of ChIP-seq, which combines chromatin immunoprecipitation (ChIP) with massively parallel DNA sequencing, to map genome-wide XBP1 binding sites in different breast cancer cell lines. We showed that HIF1M-NM-1 motif was enriched in XBP1 binding sites in triple negative breast...
ORGANISM(S): Homo sapiens 
2013-09-26 | E-GEOD-49952 | biostudies-arrayexpress
TranscriptomicsExpression data from two breast cancer cell lines
During cancer progression, carcinoma cells encounter a variety of cytotoxic stresses such as hypoxia, nutrient deprivation, and low pH as a result of inadequate vascularization. To maintain survival and growth in the face of these physiologic stressors, a set of adaptive response pathways are induce...
ORGANISM(S): Homo sapiens 
2013-09-26 | E-GEOD-49953 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization and transcription profiling of human and mouse T cells in differentiation
ChIP-Chip for T-bet and GATA-3 in human Th1 and Th2 cells, gene expression profiling of human Th1 and Th2 cells and of T-cells from T-bet-deficient mice,
ORGANISM(S): Homo sapiens 
2009-10-26 | E-TABM-759 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed genes between osteochondroprogenitor sub-populations
Cell based bone regeneration strategies offer promise for traumatic bone injuries, congenital defects, non-union fractures and other skeletal pathologies. Postnatal bone remodeling and fracture healing provide evidence that an osteochondroprogenitor cell is present in adult life which can differenti...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-64406 | biostudies-arrayexpress
TranscriptomicsExpression data from IRE1a or XBP1 deficient mouse liver
IRE1a and XBP1 are key regulators of the unfolded protein response (UPR). XBP1 ablation causes profound hypolipidemia in mice, and triggers feedback activation of its upstream enzyme IRE1a, instigating regulated IRE1-dependent decay (RIDD), an mRNA degradation mechanism dependent on IRE1a's endoribo...
ORGANISM(S): Mus musculus 
2012-10-17 | E-GEOD-40515 | biostudies-arrayexpress
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