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MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Stem cell and cell line assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS4708 | MetaboLights
MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Xenograft assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS730 | MetaboLights
MetabolomicsCell-intrinsic metabolic phenotypes identified in glioblastoma patients using mass spectrometry imaging of 13C-labeled glucose metabolism

Transcriptomic studies attempted to classify glioblastoma (GB) into subtypes that predict survival and that have different therapeutic vulnerabilities1-3. Here we identified three metabolic subtypes: glycolytic, oxidative and a mixed glycolytic/oxidative by mass spectrometry imaging of rapidly ex...

2025-05-08 | MTBLS12176 | MetaboLights
MetabolomicsHypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239
Background: Elevated choline kinase alpha (ChoK) levels are observed in most solid tumors, including glioblastomas (GBM), and ChoK inhibitors have demonstrated limited efficacy in GBM models. Given that hypoxia is associated with resistance to GBM therapy, we hypothesized that tumor hypoxia c...
2024-06-18 | MTBLS6212 | MetaboLights
MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
TranscriptomicsGlioblastoma microvesicles transport RNA and proteins
Glioblastoma tumour cells release microvesicles (exosomes) containing mRNA, miRNA and angiogenic proteins. These microvesicles are taken up by normal host cells, such as brain microvascular endothelial cells. By incorporating an mRNA for a reporter protein into these microvesicles, we demonstrate th...
ORGANISM(S): Homo sapiens 
2008-11-15 | E-GEOD-13470 | biostudies-arrayexpress
MetabolomicsMetabolic heterogeneity in Glioblastoma
Not available
ORGANISM(S): Homo sapiens 
ST000248 | MetabolomicsWorkbench
MetabolomicsNano-hijacked myeloid cells potentiate antitumor immunity and radiotherapy for glioblastoma
Not available
ORGANISM(S): Mus musculus 
ST002467 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of human short term cultured glioblastoma cell lines treated with 5-aza-2-deoxycitidine to investigate if epigenetic alterations are an alternative means of glioblastoma gene inactivation
Glioblastoma, the most aggressive and least treatable form of malignant glioma, is the most common human brain tumor. Although many regions of allelic loss occur in glioblastomas, relatively few tumor suppressor genes have been found mutated at such loci. To address the possibility that epigenetic a...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-4717 | biostudies-arrayexpress
MetabolomicsMitochondrial Transplantation of Brown Adipocytes Interferes with the Metabolism of Tumor Stem Cells and Inhibits the Recurrence of Brain Glioma after Operation

Glioblastoma multiforme (GBM) is highly aggressive, with treatment resistance and recurrence driven by metabolically plastic glioma stem cells (GSCs). Inspired by brown adipose tissue (BAT) thermogenesis, researchers transplanted BAT-derived mitochondria (BA-Mito) into GSCs, reducing stemness mar...

2025-08-27 | MTBLS12901 | MetaboLights
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