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MetabolomicsHypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239
Background: Elevated choline kinase alpha (ChoK) levels are observed in most solid tumors, including glioblastomas (GBM), and ChoK inhibitors have demonstrated limited efficacy in GBM models. Given that hypoxia is associated with resistance to GBM therapy, we hypothesized that tumor hypoxia c...
2024-06-18 | MTBLS6212 | MetaboLights
TranscriptomicsArray CGH analysis of single spheroids from glioblastoma spheroid cultures
The goal of this study was to investigate genomic aberrations of glioblastoma spheroid cultures. Keywords: Comparative genomic hybridization We performed array comparative genomic hybridization of spheroid cultures derived from 2 glioblastoma spheroid cultures using as a reference DNA from healthy ...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-14821 | biostudies-arrayexpress
TranscriptomicsMolecular analysis of glioblastoma stem cell-like spheroid cultures identifies novel tumor-relevant genes
This SuperSeries is composed of the following subset Series: GSE14818: Gene expression analysis of glioblastoma spheroid cultures I GSE14819: Array CGH analysis of glioblastoma serum grown adherent cultures GSE14820: Array CGH analysis of glioblastoma cell lines GSE14821: Array CGH analysis of singl...
ORGANISM(S): Homo sapiens 
2010-02-12 | E-GEOD-14824 | biostudies-arrayexpress
ProteomicsAdherent and Spheroid Glioblastoma Proteomics
Dendritic cell (DC)-based immunotherapy against glioblastoma multiforme is a novel treatment hope. Glioblastoma stem-like cells are, however, potentially causing immunoresistance. Glioblastoma cells cultured as gliomaspheres show a stem-like phenotype as opposed to classical adherent culture. They a...
ORGANISM(S): Homo sapiens (Human) 
2019-04-15 | PXD008244 | Pride
Dendritic cell Immunotherapy Antigen source Gliomasphere Quantitative proteomics Glioblastoma multiforme 
ProteomicsQuantitative proteomic analysis of glioblastoma subpopulations
Three glioblastoma subpopulations were analyzed by quantitative proteomics, using dimethyl labeling approach. Deconvolution of mixture spectra using SuperQuant software was employed to increase the depth of quantification.
ORGANISM(S): Homo sapiens (Human) 
2018-03-08 | PXD005245 | Pride
Glioblastoma Superquant Shotgun proteomics Cancer Lcms 
TranscriptomicsCulture media-induced transcriptional variation in lung cancer (A549), colorectal cancer (HCT116), ovarium cancer (SKOV3) and glioblastoma (U87MG) spheroids
Spheroids, near spherical multicellular aggregates, are one of the most common types of threedimensional (3D) cell cultures. Despite decades of implementation of spheroid technology in various fields of life science and medical research, no minimal information (MI) guidelines are available to cope w...
ORGANISM(S): Homo sapiens 
2021-10-01 | E-MTAB-10862 | biostudies-arrayexpress
TranscriptomicsThe angiogenic switch leads to a metabolic shift in human glioblastoma
The gene expression profiles of two groups of triplicate human glioblastoma (GBM) xenografts grown in immunodeficient rats were compared. The first group of xenografts was derived from a patient biopsy with Epidermal Growth Factor Receptor (EGFR) amplification which grows highly invasive and is ind...
ORGANISM(S): Homo sapiens 
2017-07-05 | E-MTAB-4898 | biostudies-arrayexpress
UnknownFerroptosis Enhances T Lymphocyte Infiltration into Glioblastoma Spheroids.
Not available
S-EPMC12649233 | biostudies-literature
TranscriptomicsMicroRNA profiling of human glioblastoma cell line U87 cell spheroids before and after migration on collagen
U87 cell spheroids were harvested from collagen on day 0 (no migration), or day 3 (extensive migration). The RNA extracted from these cells was used to identify microRNA alterations that occur during glioma cell line migration.
ORGANISM(S): Homo sapiens 
2010-01-28 | E-MEXP-2567 | biostudies-arrayexpress
GenomicsEvaluation of comprehensive gene expression and NK cell-mediated killing in glioblastoma cell line-derived spheroids [spheroids]
Evaluation of comprehensive gene expression and NK cell-mediated killing in glioblastoma cell line-derived spheroids [spheroids]
PRJNA756022 | ENA
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