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MetabolomicsTissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment
The discovery of the oncometabolite 2-hydroxyglutarate in isocitrate dehydrogenase 1-mutated (IDH1-mutated) tumor entities affirmed the role of metabolism in cancer. However, large databases with tissue metabolites that are modulated by IDH1 mutation remain an area of development. Here, we present a...
2022-09-07 | MTBLS3873 | MetaboLights
ModelsSturrock2015 - glioma growth
The paper describes a model of glioma. Created by COPASI 4.26 (Build 213) This model is described in the article: A mathematical model of pre-diagnostic glioma growth Marc Sturrock, Wenrui Hao, Judith Schwartzbaum, Grzegorz A. Rempala J Theor Biol. 2015 September 7; 380: 299–308 Abstract: D...
2024-09-02 | BIOMD0000000801 | BioModels
Immuno-oncology 
TranscriptomicsF11R is a novel monocyte prognostic biomarker for malignant glioma [Affymetrix]
Objective: Brain tumors (gliomas) contain large populations of infiltrating macrophages and recruited microglia, which in experimental murine glioma models promote tumor formation and progression. Among the barriers to understanding the contributions of these stromal elements to high-grade glioma (g...
ORGANISM(S): Mus musculus 
2013-11-13 | E-GEOD-46686 | biostudies-arrayexpress
TranscriptomicsF11R is a novel monocyte prognostic biomarker for malignant glioma [Seq]
Objective: Brain tumors (gliomas) contain large populations of infiltrating macrophages and recruited microglia, which in experimental murine glioma models promote tumor formation and progression. Among the barriers to understanding the contributions of these stromal elements to high-grade glioma (g...
ORGANISM(S): Mus musculus 
2013-11-13 | E-GEOD-46688 | biostudies-arrayexpress
TranscriptomicsAnalysis of microRNA expression profile in malignant glioma tissues
Malignant gliomas represent the most devastating group of brain tumors in adults, among which glioblastoma multiforme (GBM) exhibits the highest malignancy rate. Despite combined modality treatment, GBM recurs and is invariably fatal. A further insight into molecular background of gliomagenesis is r...
ORGANISM(S): Homo sapiens 
2014-09-26 | E-GEOD-61710 | biostudies-arrayexpress
TranscriptomicsExpression data from CD133+ and CD133- glioma cells
Given the very substantial heterogeneity of most human cancers, it is likely that most cancer therapeutics will be active in only a small fraction of any population of patients. As such, the development of new therapeutics, coupled with methods to match a therapy with the individual patient, will be...
ORGANISM(S): Homo sapiens 
2010-10-16 | E-GEOD-24716 | biostudies-arrayexpress
ProteomicsSecretome analysis of Cx43 expressing cells
Extracellular matrix remodeling, degradation and glioma cell motility are critical aspects of glioblastoma multiforme (GBM). Despite being a rich source of potential biomarkers and targets for therapeutic advance, the dynamic changes within the extracellular environment that are specific to GBM cell...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-04-17 | PXD012175 | Pride
Glioma Connexin Secretome Connexin43 
ProteomicsMechanistic Insight into Glioma Through Spatially Multidimensional Proteomics
Characterizing the tumor microenvironment at the molecular level is essential for understanding the mechanisms of tumorigenesis and evolution. However, the specificity of the blood proteome in localized region of the tumor and its linkages with other systems is difficult to investigate. Here, we pro...
ORGANISM(S): Homo Sapiens 
2023-07-20 | PXD043970 |
TranscriptomicsRNA-seq of the primary patient-derived GBM cell line G797 following siRNA-mediated knockdown and pcDNA3.1-Neomycin-mediated overexpression of the lncRNA HOXA10-AS
We used a machine-learning framework to systematically discover prognostic long non-coding RNAs (lncRNAs) in 9,446 patient tumors of 30 types. We identified 166 prognostic lncRNAs whose transcript abundance correlated with patient risk and improved the performance of common clinical variables and mo...
ORGANISM(S): Homo sapiens 
2021-10-02 | E-MTAB-10944 | biostudies-arrayexpress
TranscriptomicsF11R is a novel monocyte prognostic biomarker for malignant glioma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-11-13 | E-GEOD-46690 | biostudies-arrayexpress
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