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MetabolomicsUntargeted LC–MS Metabolomic Analysis of Connexin 43 in Bone Metabolism

MC3T3-E1 cells were divided into two groups: si-NC and si-Connexin43. Cx43 expression was knocked down using siRNA transfection, followed by LC–MS-based untargeted metabolomic analysis to investigate metabolic alterations associated with Connexin 43 deficiency in osteoblasts and its potential rol...

2026-09-29 | MTBLS14532 | MetaboLights
MetabolomicsPrimary Osteocyte Supernatants Metabolomic Profiling of Two Transgenic Mice with Connexin43 Dominant Negative Mutants

Osteocytes could release some small molecules (≤ 1 kDa) through gap junctions and hemichannels to extracellular environment, such as prostaglandin E2 (PGE2), nitric oxide (NO) and adenosine triphosphate (ATP), which play key roles in transferring signals between bone cells and other tissue cells....

2021-04-14 | MTBLS2358 | MetaboLights
ProteomicsMapping the anti-cancer activity of alpha-connexin carboxyl-terminal (aCT1) peptide in resistant HER2+ breast cancer
Connexin 43 (Cx43) is a protein encoded by the GJA1 gene and is a component of cell membrane structures called gap junctions, which facilitate intercellular communication. Prior evidence indicates that elevated GJA1 expression in the HER2-positive (HER2+) subtype of breast cancer is associated with ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-01 | MSV000093550 | MassIVE
TranscriptomicsConnexin-dependent transcellular transcriptomic networks in mouse brain
Microarray experiments have generally focused on magnitude of gene expression changes in pathological conditions, thereby using the method as a high throughput screen to identify candidate marker genes and/or to validate phenotypic differences. We have used novel strategies to extract additional in...
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-6355 | biostudies-arrayexpress
TranscriptomicsSertoli cell specific testicular gene expression of Connexin 43 knockout mice
Infertility observed in adult Sertoli cell (SC)-specific Connexin 43 Knockout-mice rather seems to be an effect of the disturbed SC-Germ cell (GC) crosstalk than a direct consequence of the loss of Cx43 protein in SC with important GC specific genes being mostly affected by this deletion. Identifica...
ORGANISM(S): Mus musculus 
2011-01-06 | E-GEOD-23431 | biostudies-arrayexpress
ProteomicsPolydisperse molecular architecture of connexin 26/30 heteromeric hemichannels revealed by AFM imaging
Gap junctions are arrays of intercellular channels formed by two hemichannels docked end-to-end. Each hemichannel is a hexamer containing the same or different connexin (Cx) isoform. While homomeric Cxs forms have been largely described functionally and structurally, lesser is known about heteromeri...
ORGANISM(S): Homo sapiens (Human) 
2020-09-04 | PXD020633 | Pride
Lc-ms/ms Connexin 
TranscriptomicsRac1-Induced Connective Tissue Growth Factor regulates Connexin 43 and N-Cadherin Expression in Atrial Fibrillation
Objectives: We studied the signal transduction of atrial structural remodelling that contributes to the pathogenesis of atrial fibrillation (AF). Backround: Fibrosis is a hallmark of arrhythmogenic structural remodelling but the underlying molecular mechanisms are incompletely understood. Methods: W...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-14975 | biostudies-arrayexpress
ProteomicsCo-IP (AP-MS) of Connexin-43 - Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo
Co-IP Experiment Bait: Cx43-Flag Cell line: Hela Related Publication: Gap Junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo, Maria Kotini, Elias Barriga, Jonathan Leslie, Marc Gentzel, Verena Rauschenberger, Alexandra Schambony, and Roberto Mayor
ORGANISM(S): Homo sapiens (Human) 
2018-10-16 | PXD010870 | Pride
Ap-ms Hela Co-ip 
TranscriptomicsCX43 KO vs WT cortical astrocytes
RNA samples extracted from astrocytes cultured from wild type and Cx43 null neonatal mice were dye labeled and individually co-hybridized with a reference of labeled cDNAs pooled from a variety of tissues on eight gene arrays containing 8975 mouse DNA sequences
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-580 | biostudies-arrayexpress
GenomicsAltered Cell Clusters and Upregulated Aqp1 in Connexin 50 Knockout Lens Epithemium
Altered Cell Clusters and Upregulated Aqp1 in Connexin 50 Knockout Lens Epithemium
PRJNA1153492 | ENA
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