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MetabolomicsUntargeted LC–MS Metabolomic Analysis of Connexin 43 in Bone Metabolism

MC3T3-E1 cells were divided into two groups: si-NC and si-Connexin43. Cx43 expression was knocked down using siRNA transfection, followed by LC–MS-based untargeted metabolomic analysis to investigate metabolic alterations associated with Connexin 43 deficiency in osteoblasts and its potential rol...

2026-09-29 | MTBLS14532 | MetaboLights
MetabolomicsPrimary Osteocyte Supernatants Metabolomic Profiling of Two Transgenic Mice with Connexin43 Dominant Negative Mutants

Osteocytes could release some small molecules (≤ 1 kDa) through gap junctions and hemichannels to extracellular environment, such as prostaglandin E2 (PGE2), nitric oxide (NO) and adenosine triphosphate (ATP), which play key roles in transferring signals between bone cells and other tissue cells....

2021-04-14 | MTBLS2358 | MetaboLights
ProteomicsDifferential MAPK Phosphorylation of Connexin43
MAPK family members are known to phosphorylate the c-terminal tail of connexin43 (cx43), however little is known about the preference of different MAPKs for specific cx43 phosphorylation sites. We utilized mass spectrometry to determine the cx43 sites phosphorylated in kinase assays by Erk, JNK, and...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2025-01-14 | PXD042575 | Pride
Erk Kinase assay Connexin43 P38 Gja1 Jnk Mapk 
TranscriptomicsConnexin43 null vs wildtype neonatal mouse HEART
Cy3-labeled cDNA obtained from four pools of three hearts of neonatal C57BL Cx43 null mice were compared to Cy3-labeled cDNA obtained from four pools of three hearts of neonatal C57BL wildtype mice through Cy5-labeled sample reference prepared at once for the entire experiment from aorta, brain, hea...
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-1961 | biostudies-arrayexpress
UnknownInvolvement of connexin43 in acetaminophen-induced liver injury.
Not available
S-EPMC5414847 | biostudies-literature
UnknownConnexin43 regulates osteoprotegerin expression via ERK1/2 -dependent recruitment of Sp1.
Not available
S-EPMC6369926 | biostudies-literature
UnknownConnexin43 enhances Wnt and PGE2-dependent activation of β-catenin in osteoblasts.
Not available
S-EPMC6711805 | biostudies-literature
ProteomicsNedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity
Nedd4-2 is an E3 ubiquitin ligase in which missense mutation is related to familial epilepsy, indicating its critical role in regulating neuronal network activity. However, Nedd4-2 substrates involved in neuronal network function have yet to be identified. Using mouse lines lacking Nedd4-1 and Nedd4...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-28 | PXD046450 | Pride
Ubiquitin Protein homeostasis Isobaric labeling Synaptic membranes 
UnknownConnexin43 hemichannel-mediated regulation of connexin43.
Not available
S-EPMC3584027 | biostudies-literature
UnknownRole of Akt and Ca2+ on cell permeabilization via connexin43 hemichannels induced by metabolic inhibition.
Not available
S-EPMC4476395 | biostudies-literature
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