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TranscriptomicsTranscriptional Profiling Defines the Roles of ERK and p38 Kinases in Epidermal Keratinocytes
Epidermal keratinocytes respond to extracellular influences by activating cytoplasmic signal transduction pathways that change the transcriptional profiles of affected cells. To define responses to two such pathways, p38 and ERK, we used SB203580 and PD98059 as specific inhibitors, and identified th...
ORGANISM(S): Homo sapiens 
2013-09-05 | E-GEOD-50591 | biostudies-arrayexpress
TranscriptomicsTranscription of Tnfaip3 is regulated by NF-kB and p38 via C/EBPβ in activated macrophages
Macrophages play a pivotal role in the immune system through recognition and elimination of microbial pathogens. Toll-like receptors (TLRs) on macrophages interact with microbial substances and initiate signal transduction through intracellular adapters. TLR4, which is important for the response to ...
ORGANISM(S): Mus musculus 
2015-04-28 | E-GEOD-46361 | biostudies-arrayexpress
Proteomics,MultiomicsmiR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signaling in human colorectal adenocarcinoma cells
Oxaliplatin (oxPt) resistance in colorectal cancers (CRC) is a major unsolved problem. Consequently, predictive markers and a better understanding of resistance mechanisms are urgently needed. To investigate if the recently identified predictive miR-625-3p is functionally involved in oxPt resistance...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080762 | MassIVE
GenomicsHeyndrickxia coagulans P38
BACILLUS-COAGULANS-P38
PRJNA218161 | ENA
TranscriptomicsTranscription profiling by array of left ventricle tissues from rat with overexpression of constitutively active upstream kinase mitogen-activated protein kinase kinase 3b (MKK3bE) and wild-type p38? in the heart
Mitogen-activated protein kinases (MAPKs) regulate cardiomyocyte growth and apoptosis in response to extracellular stimulation, but the downstream effectors that mediate their pathophysiological effects remain poorly understood. We determined the targets and role of p38 MAPK in the heart in vivo by ...
ORGANISM(S): Rattus norvegicus 
2009-04-25 | E-GEOD-3866 | biostudies-arrayexpress
GenomicsClostridioides difficile P38
Clostridioides difficile P38 Genome sequencing and assembly
PRJNA86007 | ENA
TranscriptomicsSex-specific control of CNS autoimmunity by p38 MAPK signaling in myeloid cells
Objective: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), characterized by a global increasing incidence driven by relapsing-remitting disease in females. p38 MAP kinase (MAPK) has been described as a key regulator of inflammatory respons...
ORGANISM(S): Mus musculus 
2013-10-29 | E-GEOD-51707 | biostudies-arrayexpress
GenomicsBacillus sp. P38
Bacillus sp. P38 Transcriptome or Gene expression
PRJNA264947 | ENA
TranscriptomicsWhole genome analysis of p38 SAPK-mediated gene expression upon stress
Cells have the ability to respond and adapt to environmental changes through the activation of stress-activated protein kinases (SAPKs). Although it has been shown that p38 SAPK signalling participates in the regulation of gene transcription, there is not a comprehensive genome-wide transcription st...
ORGANISM(S): Mus musculus 
2010-09-29 | E-GEOD-18320 | biostudies-arrayexpress
Proteomicsp38-MAPK mediated rRNA processing and translation regulation enables PrE differentiation during mouse blastocyst maturation
p38-MAPKs are stress activated kinases necessary for placental development and nutrient and oxygen transfer during murine post-implantation development. In preimplantation development, p38-MAPK activity is required for blastocyst formation. Additionally, we have previously reported its role in regul...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-28 | PXD025711 | Pride
Lc-msms P38-mapk Phosphoproteomics Human 
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