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MetabolomicsUntargeted metabolomic profiling of HCT116 cells following DHODH and JNK inhibition

Untargeted LC-MS metabolomics was used to investigate metabolic alterations associated with DHODH inhibition and JNK signaling in colorectal cancer. The study included control, DHODH inhibitor treated, JNK inhibitor treated, and combined treatment groups, with pooled quality control samples for a...

2026-08-13 | MTBLS15162 | MetaboLights
TranscriptomicsA chromatin-modifying function of JNK during stem cell differentiation
Signaling mediates cellular responses to extracellular stimuli. The c-Jun NH2-terminal kinase (JNK) pathway exemplifies one sub-group of Mitogen-activated protein (MAP) kinases, which besides established functions in stress response, also contributes to developmental processes by an unknown mechanis...
ORGANISM(S): Mus musculus 
2011-12-18 | E-GEOD-25532 | biostudies-arrayexpress
no omics definedTranscription profiling of human keratinocytes treated with JNK inhibitor vs. control reveals inhibition of JNK in keratinocyte cultures in vitro induces virtually all aspects of epidermal differentiation in vivo
In inflamed tissue, normal signal transduction pathways are altered by extracellular signals. For example, the JNK pathway is activated in psoriatic skin, which makes it an attractive target for treatment. To define comprehensively the JNK-regulated genes in human epidermal keratinocytes, we compare...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4828 | biostudies-arrayexpress
TranscriptomicsGene Regulatory Circuitry of JNK Signaling Identifies Novel Regulators of Epithelial to Mesenchymal Transition
Purpose: The purpose of this study is to investigate role of JNK signaling during EMT. Method: Transcriptome of TGF-b treated NmuMG cells along with DMSO and JNKi treated NMuMG was generated using next generation high throughput sequencing in triplicates and duplicates respectively. Reads were mappe...
ORGANISM(S): Mus musculus 
2015-07-13 | E-GEOD-54133 | biostudies-arrayexpress
TranscriptomicsSuppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development
Arterial occlusive diseases are major causes of morbidity and mortality. Blood flow to the affected tissue must be restored quickly if viability and function are to be preserved. Collaterals are artery-to-artery or arteriole-to-arteriole interconnections that can bypass an occlusion by providing an ...
ORGANISM(S): Mus musculus 
2016-08-09 | E-GEOD-71159 | biostudies-arrayexpress
TranscriptomicsExpression of JNK target genes during dorsal closure of the Drosophila embryo
Morphogenesis of an epithelium relies on the differentiation of cellular territories that further adopt specific cell behavior. During dorsal closure of the Drosophila embryo, distinct territories and several signaling pathways (JNK, Wingless, Dpp, …) bring their own contribution to the migration of...
ORGANISM(S): Drosophila melanogaster 
2010-07-07 | E-GEOD-21805 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat aortic smooth muscle cells transfected with dominant negative or upregulated JNK1 and subjected to oxidative stress
Oxidative stress-dependent genes are defined as those induced or suppressed by H2O2 treatement in rat vascular smooth muscle cells. JNK-induced genes in rat vascular smooth muscle cells are defined as those induced by adenoviruses encoding constitutively active MKK7 (caMKK7) + wild type JNK1 (wtJNK1...
ORGANISM(S): Rattus norvegicus 
2007-10-08 | E-GEOD-2190 | biostudies-arrayexpress
TranscriptomicsEts-domain transcription factor Ets21c and nuclear receptor Ftz-F1 are novel effectors of JNK promoting tumor malignancy
Cancer represents a complex family of diseases, characterized by the uncontrolled malignant growth of a particular cell type and by metastatic dissemination of these transformed cells to secondary sites. The hallmark tumor features emerge as a result of aberrant cellular signaling and pathological g...
ORGANISM(S): Drosophila melanogaster 
2015-11-04 | E-GEOD-65261 | biostudies-arrayexpress
TranscriptomicsQuantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and JNK inhibitors as a re-sensitising therapy
Glucocorticoids (GC) are pivotal in the treatment of childhood acute lymphoblastic leukaemia (ALL) but resistance is a continuing clinical problem with the underlying mechanisms still unclear. An isobaric tag proteomic approach was used to compare protein profiles of the B lineage ALL GC-sensitive c...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-63335 | biostudies-arrayexpress
TranscriptomicsExpression data from Xenopus laevis embryonic epidermis depleted for Jnk signalling
St. 14 embryos were incubated in 100mM of a Jnk inhibitor (SP600125)-0,1x MBS until stage 24. Embryonic epidermis was isolated and stored immediately in chilled (4°C) Trizol. We sought to uncover all the putative targets of Jnk expresssed in the embryonic epidermis whole embryonic skin was isolate...
ORGANISM(S): Xenopus laevis 
2016-06-24 | E-GEOD-83672 | biostudies-arrayexpress
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