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MetabolomicsMitochondrial Transplantation of Brown Adipocytes Interferes with the Metabolism of Tumor Stem Cells and Inhibits the Recurrence of Brain Glioma after Operation

Glioblastoma multiforme (GBM) is highly aggressive, with treatment resistance and recurrence driven by metabolically plastic glioma stem cells (GSCs). Inspired by brown adipose tissue (BAT) thermogenesis, researchers transplanted BAT-derived mitochondria (BA-Mito) into GSCs, reducing stemness mar...

2025-08-27 | MTBLS12901 | MetaboLights
TranscriptomicsTranscription profling of glioblastoma stem-like (GS) cell lines, conventional glioma cell lines and primary tumors
We compared a large panel of human glioblastoma stem-like (GS) cell lines, corresponding primary tumors and conventional glioma cell lines to identify cell lines that preserve the transcriptome of human glioblastomas most closely, thereby allowing identification of shared therapeutic targets. We us...
ORGANISM(S): Homo sapiens 
2011-02-12 | E-GEOD-23806 | biostudies-arrayexpress
TranscriptomicsFunctional analysis of HOXD9 in human gliomas and glioma cancer stem cells
HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. They also behave as oncogenes in some malignancies. In this study, we found high expression of the HOXD9 gene transcript in glioma cell line...
ORGANISM(S): Homo sapiens 
2011-04-16 | E-GEOD-28618 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for miR-340 overexpressing human glioma-initiating cells (GICs)
To identify functional targets of miR-340, we compared the gene expression profiles of miR-340 overexpressing human GICs with the profiles of their parental cells. The precursor form of miR-340 or control miRNA was overexpressed in glioma cells using miRNA lentiviral particles. The cells were incuba...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-61078 | biostudies-arrayexpress
ProteomicsProteomic characterization of extracellular matrix (ECM) produced by human fibroblast activation protein (FAP)-positive pericyte-like cells and glioma cells
Fibroblast activation protein (FAP) is upregulated in most cancers and represents an emerging theranostic target in oncology. In glioblastoma (GBM), FAP is predominantly expressed in mesenchymal pericyte-like cells, which contribute to GBM progression by promoting angiogenesis and glioma cell prolif...
ORGANISM(S): Homo Sapiens 
PXD045057 | panorama
TranscriptomicsDevelopment of microRNA (miRNA) expression signatures for human glioma-initiating cells (GICs)
To identify a novel miRNA that is aberrantly expressed in GICs, we analyzed differences in miRNA expression between the human GICs and glioma cell lines and neural stem cells by miRNA microarrays. We examined the miRNA expression profiles of five human GICs that were obtained from human glioma sampl...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-61079 | biostudies-arrayexpress
TranscriptomicsDevelopment of microRNA (miRNA) expression signatures for mouse glioma-initiating cells (GICs)
To identify a novel miRNA that is aberrantly expressed in GICs, we analyzed differences in miRNA expression between the mouse GICs, NSCL61 and OPCL61, showing characteristic features of cancer stem cell, and their parental cells by miRNA microarrays. neural stem cells, glioma-initiating cells (GICs)...
ORGANISM(S): Mus musculus 
2015-04-07 | E-GEOD-61080 | biostudies-arrayexpress
GenomicsGenes expression in glioma stem-like cells
Genes expression in glioma stem-like cells
PRJNA633099 | ENA
TranscriptomicsExpression profiles of mouse glioma-initiating cells.
To identify factors involved in glioma-initiating cells (GICs), we compared gene expressions between GIC-like cells and non-GICs. p53-deficient Neural stem cells (NSCs), oligodendrocyte precursor cells (OPCs), and astrocytes (ASTs) were transfected with pCMS-EGFP-HRasL61 and pBabe-neo by electropora...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-28091 | biostudies-arrayexpress
TranscriptomicsExpression profiling of mouse glioma-initiating cell-like cells (GICs) and non-GICs
To identify factors involved in glioma-initiating cells (GICs), we compared gene expression between GIC-like cells and non-GICs. Neural stem cells (NSCs) were transfected with pCMS-EGFP-HRasL61 and pBabe-neo by electroporation and cultured in 0.5 mg/ml neomycin. The GFP-positive stable NSCs (NSCL61s...
ORGANISM(S): Mus musculus 
2009-11-30 | E-GEOD-17062 | biostudies-arrayexpress
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