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TranscriptomicsCiliary neurotrophic factor induces genes associated with inflammatory response and gliosis in the retina: A gene profiling study of flow-sorted, Muller (glial) cells
Our data suggest that CNTF remodels the transcription profile of Muller (glial) cells leading to induction of networks associated with transcription, cell cycle regulation and inflammatory response. CNTF also appears to function as an inducer of gliosis in the retina. These studies provide new insig...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-27195 | biostudies-arrayexpress
Transcriptomics[E-MEXP-3786] IGF-I-induced chronic gliosis and retinal stress lead to neurodegeneration in an animal model of retinopathy
Transcription profiling by array of mouse male retinas to investigate IGF-I-induced chronic gliosis and retinal stress IGF-I exert multiple effects in different retinal cell populations in both physiological and pathological conditions. Transgenic mice overexpressing IGF-I in the retina showed impai...
ORGANISM(S): Mus musculus 
2013-04-30 | E-GEOD-46246 | biostudies-arrayexpress
TranscriptomicsIGF-I-induced chronic gliosis and retinal stress lead to neurodegeneration in an animal model of retinopathy
IGF-I exert multiple effects in different retinal cell populations in both physiological and pathological conditions. Transgenic mice overexpressing IGF-I in the retina showed impaired electroretinographic responses at 6-7 months of age that worsen with age. This retinal neuronal dysfunction was cor...
ORGANISM(S): Mus musculus 
2013-08-01 | E-MEXP-3786 | biostudies-arrayexpress
GenomicsBrillouin Microscopic Assessment of Retinal Stiffness During Reactive Müller Gliosis
Brillouin Microscopic Assessment of Retinal Stiffness During Reactive Müller Gliosis
PRJNA1290320 | ENA
GenomicsAutism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [ATAC-seq]
Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [ATAC-seq]
PRJNA1132699 | ENA
GenomicsMYC-Driven Gliosis Impairs Neuron-Glia Communication in Amyotrophic Lateral Sclerosis
MYC-Driven Gliosis Impairs Neuron-Glia Communication in Amyotrophic Lateral Sclerosis
PRJNA1153274 | ENA
GenomicsLipoxin B4 Mitigates TRPV4-Activated Muller Cell Gliosis During Ocular Hypertension
Lipoxin B4 Mitigates TRPV4-Activated Muller Cell Gliosis During Ocular Hypertension
PRJNA1312104 | ENA
GenomicsAutism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [bulk RNA-seq]
Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [bulk RNA-seq]
PRJNA1132694 | ENA
GenomicsAutism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [Microglia RNA-seq]
Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [Microglia RNA-seq]
PRJNA1132698 | ENA
TranscriptomicsBrillouin Microscopic Assessment of Retinal Stiffness During Reactive Müller Gliosis
Increased retinal stiffness can indicate reactive gliosis, fibrosis, or ECM remodeling – all hallmarks of early retinal damage due to diseases such as age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy. Here, we demonstrate that Brillouin microscopy can detect increased stiff...
ORGANISM(S): Mus musculus 
2026-02-23 | GSE302395 | GEO
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