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MetabolomicsDeletion of Gliotoxin Biosynthesis Remodels the Intra- and Extracellular Metabolic Status of Aspergillus fumigatus, Alters Its Virulence-Related Phenotypes, and Modulates Host Immune Responses_Mycelium

Gliotoxin is a secondary metabolite produced by Aspergillus fumigatus, known to play a significant role in immune regulation and virulence phenotypes. This study investigates how the deletion of gliotoxin biosynthesis remodels the metabolic state of A. fumigatus and subsequently af...

2026-05-11 | MTBLS14012 | MetaboLights
MetabolomicsDeletion of Gliotoxin Biosynthesis Remodels the Intra- and Extracellular Metabolic Status of Aspergillus fumigatus, Alters Its Virulence-Related Phenotypes, and Modulates Host Immune Responses_culture supernatant

Gliotoxin is a secondary metabolite produced by Aspergillus fumigatus, known to play a significant role in immune regulation and virulence phenotypes. This study investigates how the deletion of gliotoxin biosynthesis remodels the metabolic state of A. fumigatus and subsequently af...

2026-05-11 | MTBLS14011 | MetaboLights
TranscriptomicsFunctional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin
The opportunistic pathogenic mold Aspergillus fumigatus is an increasing cause of morbidity and mortality in immunocompromised and, in part, immunocompetent patients. Like bacteria or yeast, A. fumigatus can grow in multicellular communities by the formation of a hyphal network encased in an extrace...
ORGANISM(S): Aspergillus fumigatus 
2010-07-01 | E-GEOD-19430 | biostudies-arrayexpress
ProteomicsAspergillus fumigatus-derived gliotoxin impairs innate immune cell activation through modulating lipid mediator production in macrophages
Gliotoxin (GT), a major secondary metabolite and virulence factor of Aspergillus fumigatus, suppresses innate immunity and supports the evasion of host immune responses. Recently, we revealed that GT blocks leukotriene (LT)B4 formation by directly inhibiting LTA4 hydrolase (LTA4H) in activated human...
ORGANISM(S): Homo sapiens (Human) 
2024-11-13 | PXD045819 | Pride
Aspergillus fumigatus Lipid mediators Macrophages Gliotoxin Lc-ms/ms 
TranscriptomicsPseudomonas aeruginosa PA14 exposed to gliotoxin versus solvent control
Pseudomonas aeruginosa PA14 was precultured in SCFM2, and the OD600 was adjusted to 0.05 in 8 ml of SCFM2, in 6-well flat bottom cell culture plates. Gliotoxin (20 µM) or MeOH (solvent control) was added at log phase (optical density at 600 nm [OD600] = 0.3), and the cultures were incubated statical...
ORGANISM(S): Pseudomonas aeruginosa UCBPP-PA14 
2023-03-30 | E-MTAB-12785 | biostudies-arrayexpress
ProteomicsExposure of Aspergillus fumigatus to Klebsiella pneumoniae culture filtrate inhibits growth and stimulates gliotoxin production.
Aspergillus fumigatus is an opportunistic fungal pathogen of the lungs resulting in both chronic and acute infection. The fungus interacts with numerous bacteria that compose the microflora of the lung including Pseudomonas aeruginosa and Klebsiella pneumoniae, both common isolates from Cystic fibro...
ORGANISM(S): Aspergillus fumigatus Af293 
2023-03-11 | PXD037833 | Pride
Aspergillus Proteomics Gliotoxin Klebsiella Polymicrobial interaction 
UnknownSelf-protection against gliotoxin--a component of the gliotoxin biosynthetic cluster, GliT, completely protects Aspergillus fumigatus against exogenous gliotoxin.
Not available
S-EPMC2883607 | biostudies-literature
GenomicsPseudomonas aeruginosa PA14 exposed to gliotoxin versus solvent control
Pseudomonas aeruginosa PA14 exposed to gliotoxin versus solvent control
PRJEB60785 | ENA
UnknownDisruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production.
Not available
S-EPMC1489275 | biostudies-literature
UnknownIdentification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis.
Not available
S-EPMC3151163 | biostudies-literature
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