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MetabolomicsLeucine degradation metabolite ratio as a measure of meropenem susceptibility in carbapenem-resistant Klebsiella pneumoniae

Rapid detection of carbapenem-resistant Klebsiella pneumoniae (CRKP) is essential for effective clinical management and surveillance. This study investigated volatile organic compounds (VOCs) as phenotypic biomarkers of carbapenem resistance, with the goal of developing a translationally...

2026-06-09 | MTBLS13539 | MetaboLights
MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
MetabolomicsWhole genome sequencing and targeted metabolomics of multidrug-resistant Klebsiella pneumoniae KP21-10C
This study investigates multidrug-resistant Klebsiella pneumoniae KP21-10C using whole genome sequencing and targeted energy metabolomics. Genomic sequencing data were generated to characterize the bacterial genome, and targeted LC-MS/MS metabolomics was performed to quantify energy metabolism-relat...
2026-06-25 | MTBLS14858 | MetaboLights
MetabolomicsBioplatforms Australia: Antibiotic Resistant Sepsis Pathogens Framework Initiative (Klebsiella pneumoniae assays)

The Antibiotic Resistant Sepsis Pathogens Framework Initiative aims to develop a framework dataset of 5 sepsis pathogens (5 strains each) using an integrated application of genomic, transcriptomic, metabolomic and proteomic technologies. The pathogens included in this initiative are: Escheric...

2022-08-03 | MTBLS2322 | MetaboLights
MetabolomicsSerum Proteomic and Metabolomic Profiling of Sepsis Patients Reveals a Diagnostic Model and Mechanistic Insights into Carbapenem-Resistant Klebsiella pneumoniae Infection

Serum Proteomic and Metabolomic Profiling of Sepsis Patients Reveals a Diagnostic Model and Mechanistic Insights into Carbapenem-Resistant Klebsiella pneumoniae Infection

2026-05-18 | MTBLS14016 | MetaboLights
GenomicsDNA-Seq data of WT Klebsiella pneumoniae MGH 78578 and the Δwzi strain
To evaluate potential off-target effects of the RECKLEEN system, we sequenced the genome of the WT Klebsiella pneumoniae MGH 78578 strain and the Δwzi strain that had been generated using the RECKLEEN system.
ORGANISM(S): Klebsiella pneumoniae 
2025-08-30 | E-MTAB-15474 | biostudies-arrayexpress
MetabolomicsIdentification of BolA protein reveals a novel virulence factor in Klebsiella pneumoniae that contributes to liver abscess in mice

BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence. This study was initiated to elucidate the role of the BolA in the virulence of K. pneumoniae. Using a mous...

2022-09-13 | MTBLS2712 | MetaboLights
TranscriptomicsElucidating the RamA Regulon in Klebsiella pneumoniae
Directional RNAseq analyses was undertaken in Klebsiella pneumoniae Ecl8 and isogenic mutants Ecl8delta ramA and Ecl8delta ramR to determine the RamA regulon. All samples were grown in Luria Bertani broth until OD600 approx 0.6 prior to RNA extraction. Differential expression was determined using DE...
ORGANISM(S): Klebsiella pneumoniae 
2014-08-15 | E-ERAD-122 | biostudies-arrayexpress
TranscriptomicsComparative analysis of regulatory elements between Escherichia coli and Klebsiella pneumoniae by genome-wide transcription start site profiling [TSS-Seq]
We report the application of single-molecule-based sequencing technology for high-throughput profiling of transcription start sites for two enterobacteria: Escherichia coli and Klebsiella pneumoniae.By obtaining over fourteen billion bases of sequence from 5' RACE (rapid amplification of cDNA ends) ...
ORGANISM(S): Escherichia coli K-12 
2012-07-30 | E-GEOD-35821 | biostudies-arrayexpress
TranscriptomicsRNAseq reveals different transcriptional profils of Klebsiella pneumoniae planktonic, sessile and biofilm-dispersed cells
Purpose: The goal of this study was to use RNA-seq to define the Klebsiella pneumoniae transcriptome recorded under 5 different experimental conditions, and to identify signature genes of each condition by comparing global transcriptional profiles. Methods: mRNA profiles were generated for Klebsiell...
ORGANISM(S): Klebsiella pneumoniae 
2016-03-03 | E-GEOD-71754 | biostudies-arrayexpress
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