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MetabolomicsGlobal Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity
Obesity is tightly linked to hepatic steatosis and insulin resistance. One feature of this association is the paradox of selective insulin resistance: insulin fails to suppress hepatic gluconeogenesis but activates lipid synthesis in the liver. How lipid accumulation interferes selectively with some...
2018-04-26 | MTBLS582 | MetaboLights
GenomicsGlobal phosphoproteome and transcriptome integration of Chlamydia trachomatis infection
Global phosphoproteome and transcriptome integration of Chlamydia trachomatis infection
PRJNA411847 | ENA
ProteomicsComprehensive evaluation of RNAlater effect on proteome and phosphoproteome
Tumors such as pancreatic cancer contain a variety of enzymes including DNases, RNases and proteases which may lead to autolysis of DNA, RNA and proteins during sample processing. In general, RNAlater can be used to keep nucleic acids intact since it contains high concentrations of quaternary ammoni...
ORGANISM(S): Homo sapiens (Human) 
2019-05-06 | PXD010710 | Pride
Rnalater Proteome Phosphoproteome 
ProteomicsGlobal phosphoproteome of Leishmania mexicana developmental stages
Using a combination of phosphoproteome enrichment and tandem mass tag (TMT) labelling-based quantitative proteomic mass spectrometry (MS), we robustly identified and quantified 1,833 phosphorylated proteins across three life cycle stages of Leishmania mexicana (L. mexicana) parasite. Protein kinase ...
ORGANISM(S): Leishmania mexicana MHOM/GT/2001/U1103 
2023-10-04 | PXD043002 | Pride
Phosphoproteome Tmt labelling Leishmania 
ProteomicsCombined assessment of global proteome, phosphoproteome and N-terminal protein cleavage to characterize altered platelet functions in human Scott syndrome
The Scott syndrome is a rare bleeding disorder associated with a mutation in the gene encoding anoctamin-6 (TMEM16F). After stimulation of Ca2+-mobilizing agonists, syndromatic platelets show a reduced phosphatidylserine exposure and do not form membrane blebs. Given the central role of anoctamin-6 ...
ORGANISM(S): Homo sapiens (Human) 
2016-08-24 | PXD002883 | Pride
Phosphoproteome Human platelets N-terminal chafradic Lc-ms Proteome 
ProteomicsMurine hippocampal phosphoproteome LC-MSMS
The hippocampus plays an important role in spatial memory and the conversion of short-term to long-term memory. Several studies have reported the presence of a peripheral oscillator in the hippocampus, and have highlighted the importance of circadian regulation in memory formation. In this study we ...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-11 | PXD005669 | Pride
Circadian Hippocampus Phosphoproteome Mouse 
TranscriptomicsGlobal phosphoproteome and transcriptome integration of Chlamydia trachomatis infection
Gene expression profiles of RNA extracted at 24 or 48h from End1 cells infected with Chlamydia trachomatis or uninfected controls. This experiment forms part of the analysis of phosphoproteome changes after C.trachomatis infection.
ORGANISM(S): Homo sapiens 
2019-01-16 | GSE104166 | GEO
UnknownGlobal impact of Salmonella pathogenicity island 2-secreted effectors on the host phosphoproteome.
Not available
S-EPMC3675819 | biostudies-literature
ProteomicsGlobal proteome and phosphoproteome characterization of sepsis-induced kidney injury
Sepsis-induced acute kidney injury (S-AKI) is the most common complication in hospitalized and critically ill patients, highlighted by a rapid decline of kidney function occurring a few hours or days after sepsis onset. Systemic inflammation elicited by microbial infections is believed to lead to ki...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000086126 | MassIVE
ProteomicsMulti-Omic Signatures of Thyroid Damage in Age-Related Subclinical Hypothyroidism
Age-associated subclinical hypothyroidism (AR-SCH) causes severe structural and functional damage to thyroid glands in aged populations, but the global molecular mechanisms governing AR-SCH pathogenesis are largely unclear. We constructed an exhaustive multi-omic map of thyroid tissues from AR-SCH m...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-28 | PXD080737 | Pride
Subclinical hypothyroidism Mouse Proteomics Multi-omics 
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