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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
MetabolomicsPROMIS, global analysis of PROtein-Metabolite Interactions using Size separation in Arabidopsis thaliana
Small molecules not only represent cellular building blocks and metabolic intermediates, but also regulatory ligands and signaling molecules that interact with proteins. Although these interactions affect cellular metabolism, growth, and development, they have been largely understudied. Herein, we d...
2018-07-19 | MTBLS94 | MetaboLights
MetabolomicsImproving global feature detectabilities through scan range splitting for untargeted metabolomics by high-performance liquid chromatography-Orbitrap mass spectrometry
Untargeted metabolomics aims at obtaining quantitative information on the highest possible number of low-molecular biomolecules present in a biological sample. Rather small changes in mass spectrometric spectrum acquisition parameters may have a significant influence on the detectabilities of metabo...
2016-06-09 | MTBLS233 | MetaboLights
MetabolomicsAn Integrated Biochemical, Proteomics, and Metabolomics Approach for Supporting Medicinal Value of Panax ginseng Fruits (GC-MS assay)
Panax ginseng roots are well known for their medicinal properties and have been used in Korean and Chinese traditional medicines for 1000s of years. However, the medicinal value of P. ginseng fruits remain poorly characterized. Using gas chromatography-time of flight mass spectrometry (GC-TOF MS), 6...
2016-11-18 | MTBLS350 | MetaboLights
UnknownQuantitative proteomics in cardiovascular research: global and targeted strategies.
Not available
S-EPMC4159306 | biostudies-literature
ProteomicsAn Integrated Quantitative Proteomics Workflow for Biomarker Discovery and Validation in Plasma
Blood plasma is one of the most widely used samples for biomarker discovery research as well as clinical investigations for diagnostic and therapeutic purposes. However, the plasma proteome is extremely complex due to its wide dynamic range of protein concentrations and the presence of high-abundanc...
ORGANISM(S): Homo sapiens (Human) 
2020-09-07 | PXD017834 | Pride
Targeted proteomics Label-based quantitation Label-free quantitation 
UnknownComparative and Quantitative Global Proteomics Approaches: An Overview.
Not available
S-EPMC5302699 | biostudies-literature
ProteomicsGlobal quantitative proteomics reveals novel factors in the ecdysone signaling pathway in Drosophila melanogaster.
Global quantitative proteomics reveals novel factors in the ecdysone signaling pathway in Drosophila melanogaster.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2015-01-23 | PXD001455 | Pride
Q exactive Ecdysone signaling Silac Drosophila melanogaster 
UnknownQuantitative proteomics analysis of the Arg/N-end rule pathway of targeted degradation in Arabidopsis roots.
Not available
S-EPMC4692092 | biostudies-literature
ProteomicsQuantitative Analysis of Global Proteome in Wheat Germ
Using iTRAQ labeling and HPLC fractionation followed by high-resolution LC-MS/MS analysis, quantitative global proteome analysis was performed. In total, 6538 protein groups were identified from Triticum_aestivum, among which 2766 proteins were quantified.
ORGANISM(S): Triticum aestivum (Wheat) 
2016-09-29 | PXD004564 | Pride
Wheat germ Global proteome 
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