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GenomicsEffect of p53 knowkdown on genome-wide map of AR-DNA binding
We report that p53 knockdown changed AR-DNA binding across the genome. We found fewer AR-binding sites in the absence of p53. Examination of AR-DNA binding after p53 knockdown in LNCaP cells
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-31294 | biostudies-arrayexpress
UnknownComparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial.
Not available
S-EPMC9418415 | biostudies-literature
MetabolomicsSex-specific effects of CD248 on metabolism and the adipose tissue lipidome

Cd248 has recently been associated with adipose tissue physiology, demonstrated by reduced weight gain in high fat diet-fed mice with genetic deletion of Cd248 relative to controls. Here we set out to determine the metabolic consequences of loss of Cd248. Strikingly, we find these to be sex speci...

2023-01-05 | MTBLS6615 | MetaboLights
TranscriptomicsTranscription profiling of R1 embryonic stem cells treated with :to DMSO and retinoic acid vs control
Comparison of R1 embryonic stem cells response to DMSO and retinoic acid and control
ORGANISM(S): Mus musculus 
2006-10-27 | E-MEXP-412 | biostudies-arrayexpress
TranscriptomicsLimb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women
Advancements in animal models and cell culture techniques have been invaluable in the elucidation of molecular events and mechanisms regulating muscle atrophy. However, few studies have examined muscle atrophy in humans using modern experimental techniques. The purpose of this study was to examine a...
ORGANISM(S): Homo sapiens 
2009-02-21 | E-GEOD-14901 | biostudies-arrayexpress
TranscriptomicsSpotted Dick Chromatin Immunopurification
Chromatin enriched by immunopurification with antibodies against the Drosophila transcription factor spotted dick compared with pre immune sera on a cDNA microarray
ORGANISM(S): Drosophila melanogaster 
2010-06-10 | E-GEOD-2632 | biostudies-arrayexpress
TranscriptomicsBru-seq nascent RNA sequencing of human and mouse cells: correlation to replication timing and genome instability
Bru-seq nascent RNA sequencing (PubMed ID 23973811) was performed on two primary human fibroblast cell lines, mouse embryonic stem cells, and GM12878 human lymphoblastoid cells. Read data, which include both exon and intron signals, were used to identify transcription unit spans genome-wide, where a...
ORGANISM(S): Homo sapiens 
2014-10-17 | E-GEOD-55862 | biostudies-arrayexpress
UnknownAutologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial.
Not available
S-EPMC11922741 | biostudies-literature
TranscriptomicsHigh throughput decoding of anti trypanosomal drug efficacy and resistance
We used all five current human African trypanosomiasis drugs for genome-scale RNA interference (RNAi) target sequencing (RIT-seq) screens in Trypanosoma brucei, revealing the transporters, organelles, enzymes and metabolic pathways that function to facilitate anti-trypanosomal drug action. RIT-seq p...
ORGANISM(S): Trypanosoma brucei 
2011-11-29 | E-ERAD-30 | biostudies-arrayexpress
TranscriptomicsTranscriptome comparisons of wild, domesticated and hybrid Atlantic salmon fry under stress and control conditions
This study compares the transcriptomes of wild and domesticated Atlantic salmon strains and their transcriptional response to acute stress. Microarray interrogations consisted of 48 hybridizations; 4 crosses (pure wild; Figgjo x Figgjo, pure domesticated; Mowi x Mowi and their reciprocal hybrids; Fi...
ORGANISM(S): Salmo salar 
2015-08-31 | E-MTAB-3679 | biostudies-arrayexpress
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