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ProteomicsGLP-1R and GIPR heterodimerization and expression determine downstream signaling and metabolic phenotypes
Advancements in unimolecular drugs co-targeting the glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) have demonstrated remarkable clinical efficacy in treating type 2 diabetes (T2D) and obesity. However, the paradoxical ability of both GIPR a...
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD063931 | Pride
Pancreatic islets Phosphoproteomics Glp-1r 
ProteomicsGLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function
Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RAs) ameliorate mitochondrial health by increasing mitochondrial turnover in metabolically relevant tissues. Mitochondrial adaptation to metabolic stress is crucial to maintain pancreatic -cell function and prevent type 2 diabetes (T2D) progre...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-09-30 | PXD056782 | Pride
Membrane contact sites Pancreatic beta cells Mitochondrial remodelling Akaps Er-mitochondrial contacts Incretins Sphkap Compartmentalised pka signalling Glp-1r Vap-b 
TranscriptomicsEffects of exendin-4 in Brunner's glands of male GLP-1R-/- and wild-type control mice
To gain insight into the biological functions of the highly expressed GLP-1R in Brunner’s glands, transcriptome analyses were conducted in male GLP-1R-/- and wild-type control mice. Analyses were performed 6 hours after a single s.c. dose of exendin-4 (1.0mg/kg s.c.), following 18 hours of two d...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-80119 | biostudies-arrayexpress
GenomicsFunctional and multi-omic aging rejuvenation with GLP-1R agonism
Functional and multi-omic aging rejuvenation with GLP-1R agonism
PRJNA1172703 | ENA
GenomicsGLP-1R agonist semaglutide protects developing human forebrain organoids from cholesterol-induced neurotoxicity—scRNA sequence
GLP-1R agonist semaglutide protects developing human forebrain organoids from cholesterol-induced neurotoxicity—scRNA sequence
PRJNA1460827 | ENA
UnknownInactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection.
Not available
S-EPMC4099509 | biostudies-literature
UnknownSmall peptide-based GLP-1R ligands: an approach to reduce the kidney uptake of radiolabeled GLP-1R-targeting agents?
Not available
S-EPMC8387526 | biostudies-literature
UnknownPSCs and GLP-1R: occurrence in normal pancreas, acute/chronic pancreatitis and effect of their activation by a GLP-1R agonist.
Not available
S-EPMC3879597 | biostudies-literature
UnknownRegulation of adipocyte formation by GLP-1/GLP-1R signaling.
Not available
S-EPMC3307265 | biostudies-literature
UnknownBiased agonism of GLP-1R and GIPR enhances glucose lowering and weight loss, with dual GLP-1R/GIPR biased agonism yielding greater efficacy.
Not available
S-EPMC12208311 | biostudies-literature
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