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ProteomicsGLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function
Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RAs) ameliorate mitochondrial health by increasing mitochondrial turnover in metabolically relevant tissues. Mitochondrial adaptation to metabolic stress is crucial to maintain pancreatic -cell function and prevent type 2 diabetes (T2D) progre...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-09-30 | PXD056782 | Pride
Membrane contact sites Pancreatic beta cells Mitochondrial remodelling Akaps Er-mitochondrial contacts Incretins Sphkap Compartmentalised pka signalling Glp-1r Vap-b 
UnknownGLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function.
Not available
S-EPMC12338517 | biostudies-literature
UnknownGLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function.
Not available
S-EPMC12696101 | biostudies-literature
GenomicsGenome-wide study of DNA methylation in AML by MeDIP-seq
Methylated DNA immunoprecipitation followed by high-throughput sequencing (MeDIP-seq) has the potential to identify changes in DNA methylation important in cancer development. In order to understand the role of epigenetic modulation in the development of acute myeloid leukemia (AML) we have applied ...
ORGANISM(S): Homo sapiens 
2012-04-02 | E-GEOD-28314 | biostudies-arrayexpress
UnknownNeuronal ER-plasma membrane junctions couple excitation to Ca2+-activated PKA signaling.
Not available
S-EPMC10460453 | biostudies-literature
UnknownWhole-Exome Sequencing Identifies Damaging de novo Variants in Anencephalic Cases.
Not available
S-EPMC6896715 | biostudies-literature
TranscriptomicsBipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
Human genomic studies have identified protein-truncating variants in AKAP11 associated with both bipolar disorder (BD) and schizophrenia (SCZ), implicating a shared disease mechanism driven by loss-of-function. AKAP11, a protein kinase A (PKA) adaptor, plays a key role in degrading the PKA-RI comple...
ORGANISM(S): Mus musculus 
2025-12-09 | GSE304457 | GEO
UnknownSphingosine kinase 1-interacting protein is a novel regulator of glucose-stimulated insulin secretion.
Not available
S-EPMC5429731 | biostudies-literature
UnknownWhole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas.
Not available
S-EPMC3240977 | biostudies-literature
UnknownBipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission.
Not available
S-EPMC12663438 | biostudies-literature
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