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MetabolomicsAkkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease
The gut microbiome is a key factor regulating energy-metabolism, glucose tolerance and the immune system. Akkermansia muciniphila has been identified as being beneficial gut bacterium for metabolic diseases, including obesity and type 2 diabetes (T2D); however, the molecular mechanisms involved in h...
2021-01-13 | MTBLS1824 | MetaboLights
GenomicsNobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion - 16S
16S rRNA gene sequencing of colonic feces from mice fed regular chow, regular chow+nobiletin, high-fat diet or high-fat diet+nobiletin.
ORGANISM(S): Mus musculus 
2022-05-06 | E-MTAB-11551 | biostudies-arrayexpress
TranscriptomicsCOUP-TFII Controls Mouse Postnatal Pancreatic β-Cell Mass through GLP-1 β-Catenin
Pancreatic β-cells have the key homeostatic function of releasing insulin to keep blood glucose in the normal range. It is not fully understood how β-cell mass is determined. Ablation of a nuclear receptor, chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), in mouse pancreat...
ORGANISM(S): Rattus norvegicus 
2011-10-06 | E-GEOD-30526 | biostudies-arrayexpress
GenomicsBI 456906: a dual glucagon-like peptide-1/glucagon agonist promoting bodyweight reduction
BI 456906: a dual glucagon-like peptide-1/glucagon agonist promoting bodyweight reduction
PRJNA868929 | ENA
GenomicsChronic treatment with glucagon-like peptide-1/glucagon receptor co-agonist causes weight-loss independent improvements in hepatic steatosis
Chronic treatment with glucagon-like peptide-1/glucagon receptor co-agonist causes weight-loss independent improvements in hepatic steatosis
PRJNA1019376 | ENA
GenomicsMolecular Connectomics Reveals a Glucagon-Like Peptide 1 Sensitive Neural Circuit for Satiety
Molecular Connectomics Reveals a Glucagon-Like Peptide 1 Sensitive Neural Circuit for Satiety
PRJNA1162854 | ENA
TranscriptomicsExendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice
Traumatic brain injury (TBI) is a global problem reaching near epidemic numbers that manifests clinically with cognitive problems that decades later may result in dementias like Alzheimer’s disease (AD). Presently, little can be done to prevent ensuing neurological dysfunctions by pharmacological me...
ORGANISM(S): Mus musculus 
2012-10-17 | E-GEOD-41345 | biostudies-arrayexpress
TranscriptomicsSingle-nucleus RNA-seq of FACS-enriched Glp1r-Sun1-sfGFP nuclei from mouse hypothalamus, dorsal vagal complex, and nodose ganglion
Glucagon-like peptide-1 receptor (GLP1R) agonists such as semaglutide reduce food intake and body weight, and Glp1r-expressing neurons in the hypothalamus and hindbrain mediate these effects. To profile these cells directly, Glp1r-Cre mice were crossed to the Gt(ROSA)26Sor-CAG-Sun1-sfGFP reporter, w...
ORGANISM(S): Mus musculus 
2026-09-14 | E-MTAB-17566 | biostudies-arrayexpress
TranscriptomicsBI 456906: a dual glucagon-like peptide-1/glucagon agonist promoting bodyweight reduction
Glucagon and glucagon-like peptide-1 (GLP-1) are hormones involved in energy homeostasis. GLP-1 receptor (GLP-1R) agonism reduces food intake and delays gastric emptying, and glucagon receptor (GCGR) agonism increases energy expenditure by thermogenesis. BI 456906 is a subcutaneous, once-weekly inje...
ORGANISM(S): Mus musculus 
2022-12-09 | GSE211105 | GEO
GenomicsGlucagon-like peptide-1 suppresses sympathetic activation via peripheral chemosensory inhibition
Glucagon-like peptide-1 suppresses sympathetic activation via peripheral chemosensory inhibition
PRJNA739448 | ENA
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