OBJECTIVE: Emerging evidence suggests that glucose depletion (GD)-induced cell death depends on system Xc-, a glutamate/cystine antiporter extensively studied in ferroptosis. However, the underlying mechanism remains debated. Our study confirmed the correlation between system Xc...
This is a transcription profiling study on yeast undergoing glucose depletion. It reveals that glucose depletion inhibits translation initiation in a mechanism involving eIF4A loss and 48S pre-initiation complex accumulation, while the pentose phosphate pathway is co-ordinately up-regulated
Inorganic nutrient deficiency stimulates polymer synthesis in bacterial producers relevant to wastewater treatment and biotechnology, but the metabolic mechanisms are poorly understood. Here, using a quantitative multi-omics analysis of the wastewater isolate Comamonas testosteroni durin...
Several studies indicated anti-cancer effects of metformin in liver cancer. This was attributed to the activation of LKB-AMPK axis, which is associated with anti-hyperglycaemic effect and cytotoxicity. However, glucose- and central carbon-independent effects of metformin ...
This is a polysome/monosome profiling study on yeast undergoing glucose depletion. Polysomes and monosomes are extracted and the transcripts bound to each fraction are measured by microarray. The study reveals that glucose depletion inhibits translation initiation in a mechanism involving eIF4A loss...
There is growing evidence to support the idea that the accumulation of reactive carbonyl species plays a significant causal role in the pathogenesis of ageing, cardiovascular diseases, diabetes and its complications. Among reactive carbonyl species, methylglyoxal and acrolein, detoxified by glyox...
Quantifying the Contribution of the Liver to Glucose Homeostasis: A Detailed Kinetic
Model of Human Hepatic Glucose Metabolism
Kinetic Model of Human Hepatic Glucose Metabolism
Authors
Matthias Koenig, Sasc...
Kinetic Modeling of Human Hepatic Glucose Metabolism in
Type 2 Diabetes Mellitus Predicts Higher Risk of
Hypoglycemic Events in Rigorous Insulin Therapy*
Kinetic Model of Human Hepatic Glucose Metabolism in T2DM
Authors
...
