Glutamatergic - OmicsDI

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Unknown (4543)
Genomics (577)
Transcriptomics (452)
Proteomics (76)
Other (22)
Methylation profiling (13)
Metabolomics (5)
Models (2)
Genomic (1)

Organisms

Mus musculus (283)
Homo sapiens (157)
Aerococcus urinae NBRC 15544 = CCUG 36881 (62)
Andropogon gerardi (62)
Bacteria (62)
Bartonella quintana JK 31 (62)
Canis lupus familiaris (62)
Cnidaria (62)
Rattus norvegicus (57)
Drosophila melanogaster (13)
Danio rerio (10)
Pleurodeles waltl (9)
Caenorhabditis elegans (4)
Macaca mulatta (4)
Ovis aries (3)
Lonchura striata (2)
Taeniopygia guttata (2)
synthetic construct (2)
Gallus gallus (2)
Pan troglodytes (2)
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Amphiprion ocellaris (1)
Mus musculus domesticus (1)
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Sus scrofa (1)
Xenopus laevis (1)
Mus (1)

Organisms

Mus musculus (235)
Homo sapiens (118)
Rattus norvegicus (44)
Drosophila melanogaster (13)
Pleurodeles waltl (9)
Danio rerio (9)
Caenorhabditis elegans (3)
Lonchura striata (2)
Mus musculus domesticus (2)
Taeniopygia guttata (2)
Ovis aries (2)
Amphiprion ocellaris (1)
Synthetic plasmid (1)
Columba livia (1)
Xenopus laevis (1)
Sus scrofa (1)

Repository

ENA (528)
geo (445)
biostudies-arrayexpress (87)
pride (62)
MassIVE (10)
MetaboLights (5)
EGA (4)
iProX (4)
BioModels (2)
dbGaP (1)

Tissue

Brain (47)
Cell culture (9)
Glutamatergic neuron (3)
Hippocampus (3)
Astrocyte (1)
CNS neuron (sensu Vertebrata) (1)
Central nervous system neuron (1)
Cerebral cortex neuron (1)
Cerebral cortex pyramidal neuron (1)
Cerebrospinal fluid (1)
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Ganglionic layer of retina (1)
Generation of neurons (1)
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Liver (1)
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Neuron (1)
Neuronal stem cell (1)
Pluripotent stem cell (1)
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Telencephalon (1)

Disease

Alzheimer's disease (6)
Fragile X syndrome (3)
Parkinson's disease (3)
Normal (1)
Amyotrophic lateral sclerosis (1)
Autism spectrum disorder (1)
GM1 gangliosidosis (1)
Glaucoma (1)
Huntington Disease (1)
Leigh disease (1)
Neurodegenerative disease (1)
Post-traumatic stress disorder (1)
Schizophrenia (1)
Tay-Sachs disease (1)
Wounds and Injuries (1)

Technology Type

Mass Spectrometry (62)
Shotgun proteomics (25)
Bottom-up proteomics (11)
Affinity purification coupled with mass spectrometry proteomics (9)
Data-dependent acquisition (9)
Data-independent acquisition (5)
SWATH MS (5)
Mass spectrometry assay (3)
Gel-based experiment (3)
Mass spectrometry (2)
Top-down proteomics (2)
HDMSE (1)

Instrument Platform

Illumina NovaSeq 6000 (12)
Illumina HiSeq 2500 (4)
Illumina HiSeq 2000 (4)
Illumina HiSeq 4000 (3)
NextSeq 500 (3)
Single-Cell Extraction: For enzymatic digestion, pronase (Septomyces argeus, 1 mg/mL) was applied for 25 minutes at room temperature for P0 to P8 datasets. Cells were dissociated and triturated into a single-cell suspension in ACSF supplemented with 1% fetal calf serum (FCS) and DNase (1 µL/10 mL). Trituration was performed using three glass Pasteur pipettes of decreasing diameters. For P30 datasets, enzymatic digestion and cell dissociation were carried out using the Worthington Papain Dissociation System, following the manufacturer’s instructions. Single-Nuclei Extraction: For nuclei isolation, the Hibernate™-E Medium was removed, and 500 µL of chilled 0.1X NP40 Lysis Buffer was added. Tissue was homogenized using a Pellet Pestle (15 strokes) and incubated on ice for 5 minutes. The suspension was pipette-mixed 10 times using a wide-bore pipette tip and incubated for an additional 10 minutes on ice. Following lysis, 500 µL of chilled wash buffer was added, and the mixture was pipette-mixed 5 times using a regular-bore pipette tip. The suspension was filtered through a 30 µm cell strainer into a 50 mL tube to remove debris. The filtered suspension was transferred to a 1.5 mL tube and centrifuged at 950 × g for 10 minutes at 4°C. The supernatant was carefully removed, and the nuclei pellet was retained for downstream analysis. (2)
Sequel IIe (2)
PromethION (2)
Orbitrap Eclipse (2)
Orbitrap Fusion Lumos (2)
Liquid Chromatography MS - positive - reverse phase (2)
Liquid Chromatography MS - negative - reverse phase (2)
Liquid Chromatography MS - negative - hilic (2)
Liquid Chromatography MS - positive - hilic (2)
Chromium Next GEM Chip G (1)
10X v3 (1)
Not (1)
Illumina NovaSeq X (1)
Orbitrap Astral (1)
Orbitrap Fusion (1)
Q Exactive HF-X (1)
QTRAP 6500 (1)
Synapt MS (1)
TimsTOF Pro (1)
TripleTOF 6600 (1)
Liquid Chromatography MS - (1)

Publication Date

2026 (100)
2024 (81)
2025 (80)
2022 (59)
2023 (50)
2021 (47)
2020 (47)
2016 (27)
2019 (27)
2012 (15)
2018 (13)
2014 (11)
2013 (11)
2011 (11)
2015 (9)
2017 (7)
2007 (5)
2010 (3)
2005 (2)
2009 (2)
2008 (2)
2006 (2)
2004 (1)

UNIPROT ID/AC

P42263 (1)
Q13002 (1)

CHEBI ID

CHEBI:18237 (2)
CHEBI:36090 (2)
CHEBI:17634 (2)
CHEBI:17562 (2)
CHEBI:17568 (2)
CHEBI:16704 (2)
CHEBI:16750 (2)
CHEBI:57589 (2)
CHEBI:17596 (2)
CHEBI:17368 (2)
CHEBI:89416 (1)
CHEBI:89059 (1)
CHEBI:169166 (1)
CHEBI:35021 (1)
CHEBI:192102 (1)
CHEBI:36492 (1)
CHEBI:34131 (1)
CHEBI:34128 (1)
CHEBI:75133 (1)
CHEBI:33993 (1)
CHEBI:88917 (1)
CHEBI:177252 (1)
CHEBI:170583 (1)
CHEBI:177283 (1)
CHEBI:89513 (1)
CHEBI:89512 (1)
CHEBI:88918 (1)
CHEBI:177261 (1)
CHEBI:171349 (1)
CHEBI:81469 (1)

Metabolite Name

Uracil (3)
Cytidine (3)
Hypoxanthine (3)
Phenol, 2-[4-[(3,5-dichlorophenyl)amino]-6-methyl-2-pyrimidinyl]- (2)
4-Amino-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid (2)
Arachidonic sulfonic acid (2)
4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)- (2)
7-Hydroxy-6-methoxy-3-methyl-5-(propan-2-ylidene)furo[2,3,4-de]chromen-2(5H)-one (2)
GDP-mannose (2)
3-Methyl-1H-pyrazole-4-carbaldehyde (2)
Adenylsuccinic acid (2)
Lys-Asp (2)
LysoPC(22:1(13Z)) (2)
N1-Methyl-2-pyridone-5-carboxamide (2)
Glutamate (2)
PC(16:0/16:0) (2)
LysoPC(18:1(11Z)) (2)
LysoPC(20:2(11Z,14Z)) (2)
6-Benzyl-3-butan-2-yl-9-(7-hydroxy-6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone (2)
MES (2)
LPG(18:1(9Z)) (2)
5-Aminopentanoic acid (2)
O-Acetylserine (2)
Ile-Leu (2)
Ala-Glu (2)
Valine (2)
2-Aminopurine (2)
Stearidonic acid (2)
Sphingosine (2)
Sphinganine (2)

IsPrivate

False (2)

Model Flag

Non Miriam (1)

First Public Date

2024 (83)
2026 (80)
2025 (80)
2022 (56)
2021 (45)
2023 (44)
2020 (44)
2019 (27)
2014 (20)
2018 (16)
2016 (15)
2017 (8)
2015 (6)
2013 (4)

Modelling Approach

Ordinary differential equation model (2)

Study type

Transcription profiling by array (44)
RNA-seq of coding RNA (16)
RNA-seq of coding RNA from single cells (8)
ChIP-seq (5)
RNA-seq of total RNA (3)
Animal - High-throughput sequencing (2)
GRO-seq (1)
Transcription profiling by SAGE (1)
ChIP-chip by tiling array (1)
CLIP-seq (1)
Comparative genomic hybridization by array (1)
ATAC-seq (1)
Methylation profiling by array (1)
Methylation profiling by high throughput sequencing (1)
RNA-seq of non coding RNA (1)

Release Date

2025 (449)
2023 (444)
2022 (444)
2021 (426)
2024 (381)
2020 (353)
2019 (306)
2018 (263)
2017 (251)
2016 (235)
2015 (203)
2014 (172)
2013 (109)
2012 (101)
2011 (90)
2026 (88)
2009 (70)
2010 (63)
2008 (52)
2007 (36)
2006 (27)
2005 (20)
2004 (20)
2003 (11)
2002 (7)
1999 (2)
1998 (2)
2001 (1)
2000 (1)
1997 (1)

Lab affiliation

Key Laboratory of Brain Functional Genomics of Shanghai and Ministry of Education, Institute of Brain Functional Genomics, School of Life Science and the Collaborative Innovation Center for Brain Science, East China Normal University, Shanghai, China (3)
Department of Neurology, Yale School of Medicine, Yale University, new haven CT, USA (2)
1) 1Mitochondrial Neuropathology laboratory, Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain 2) Department of Cellular Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra, Spain. (1)
1. CERVO Brain Research Centre, Quebec Mental Health Institute; Québec, QC, G1E 1T2, Canada. 2. Department of Psychiatry & Neuroscience, Université Laval; Québec, QC, G1V 0A6, Canada. (1)
Bernstein Professor Emeritus in Adult Psychiatry Department of Psychiatry and Behavioral Sciences University of Minnesota Medical School (1)
Bioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, Germany Bioanalytics, Institute for Clinical Chemistry, University Medical Center Goettingen, Germany (1)
Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic (1)
Biomedical Research Institute of Lleida Dr. Pifarré Foundation (IRBLLEIDA) - +Pec Proteomics Research Group (+PPRG) - Neuroscience Area – University Hospital Arnau de Vilanova (HUAV), 80 Av. Rovira Roure, 25198, Lleida, Spain Department of Medical Basic Sciences, University of Lleida (UdL), +Pec Proteomics Research Group (+PPRG), 25198, Lleida, Spain (1)
Biomedical Research Institute, Foundation for Research and Technology-Hellas, University Campus, 45110 Ioannina, Greece (1)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, 3584 CH Utrecht, the Netherlands. (1)
Cambridge Institute for Medical Research, University of Cambridge (1)
Center for Diagbostik, Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Germany (1)
Center for Neuroscience and Cell Biology (1)
Centre for Discovery Brain Sciences, University of Edinburgh, UK; Simons Initiative for the Developing Brain, University of Edinburgh, UK (1)
Cornell University (1)
Departamento de Fisiologia, Laboratório de Fisiologia da Nutrição, Universidde Federal de São Paulo, Brasil (1)
Department Functional Proteomics Medizinisches Proteom-Center Ruhr-University Bochum Building ProDi Gesundheitscampus 4 44780 Bochum Germany (1)
Department for Neurology Section Translational Neuroimmunology Jena University Hospital Am Klinikum 1, D-07747 Jena, Germany (1)
Department of Basic and Clinical Neuroscience, The Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology, & Neuroscience, King’s College London, London, UK (1)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States (1)
Department of Biochemistry, University of Otago, New Zealand (1)
Department of Fundamental Neurosciences, Université de Lausanne, 1005 Lausanne, Switzerland & Department of Biomedicine and Prevention, Università degli studi di Roma "Tor Vergata", 00133 Rome, Italy (1)
Department of Molecular Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW, Australia (1)
Department of Neurology, Yale University, New Haven, CT, USA (1)
Department of Pharmacology & Chemical Biology W1351 Thomas Starzl Biomedical Science Tower, 200 Lothrop St,Pittsburgh, PA 15261 (1)
Department of Physiological Genomics, Biomedical Center, Ludwig-Maximilians University, Germany (1)
Department of Psychiatry, University of Pittsburgh (1)
Dept of Neurology University Hospital RWTH Aachen Pauwelsstrasse 30 52074 Aachen Germany (1)
Division of Systems and Cellular Medicine School of Medicine University of Dundee (1)
Dysmetabolism in Brain Diseases Lab, CEDOC, NOVA Medical School, Universidade NOVA de Lisboa, Rua CÃƒÂ¢mara Pestana, NÃ‚Âº 6, EdifÃƒÂcio CEDOC II, Office 2.27, 1150-082 Lisboa, Portugal (1)

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Excoriation Disorder Is Characterized by Systemic Glutamatergic Dysfunction

Excoriation disorder (ED), also known as neurotic excoriations, is a psychocutaneous disorder characterized by repetitive, compulsive picking of the skin leading to secondary tissue damage. ED carries an estimated prevalence of 1.4%, and is associated with significant social dysfunction, as patie...

2024-04-03 | MTBLS9118 | MetaboLights

Gene expression profiles of glutamatergic neuron progenitors (Neurod6-positive cells)

ORGANISM(S): Mus musculus

2012-12-08 | E-MTAB-893 | biostudies-arrayexpress

DLK-dependent protein network regulates hippocampal glutamatergic neuron degeneration

PRJNA1108218 | ENA

Neddylation regulate the development of glutamatergic neurons

PRJNA1124090 | ENA

Sleep need driven oscillation of glutamatergic synaptic phenotype

PRJNA1078321 | ENA

Cholinergic stress signals promote microRNA-mediated stereotypic behavior via glutamatergic neuromodulation

PRJNA602520 | ENA

Common schizophrenia risk variants are implicated in the function of glutamatergic neurons

PRJNA601202 | ENA

Demyelination-Induced Glutamatergic Imbalance Mediates Hippocampal Hyperexcitability

PRJNA1333491 | ENA

Glycation modulates glutamatergic signaling and exacerbates ParkinsonÃ¢â‚¬â„¢s disease-like phenotypes

Alpha-synuclein (aSyn) is a central player in the pathogenesis of synucleinopathies due to its accumulation in typical protein aggregates in the brain. However, it is still unclear how it contributes to neurodegeneration. Type-2 diabetes mellitus is a risk factor for ParkinsonÃ¢â‚¬â„¢s disease (PD) ...

ORGANISM(S): Mus musculus (Mouse)

2022-05-20 | PXD032832 | Pride

RNA-seq of NGLY1-deficient patient-derived iPSC glutamatergic neurons

PRJNA1463270 | ENA

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