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TranscriptomicsMethionine Sulfoximine Resistance in Mycobacterium tuberculosis Is Due to a Single Nucleotide Deletion Resulting in Increased Expression of the Major Glutamine Synthetase, GlnA1.
We investigated the effect of methionine sulfoximine (MetSox), a potent inhibitor of glutamine synthetase, on Mycobacterium tuberculosis. M. tuberculosis encodes four glutamine synthetases, of which MetSox targets the type I enzyme encoded by glnA1. Trancriptional profiling revealed that glutamate s...
ORGANISM(S): Mycobacterium tuberculosis 
2011-09-06 | E-BUGS-112 | biostudies-arrayexpress
MetabolomicsMulti-omics analysis identifies gut microbiota-glutamine axis contributing to the pathogenesis of reflux esophagitis

Background: Reflux esophagitis (RE), a common gastroesophageal reflux disease characterized by esophageal mucosal inflammation, is closely associated with gut microbiota dysbiosis and metabolic abnormalities. The glutamine-glutamate metabolic pathway regulates inflammation and mucosal barrier fun...

2026-05-03 | MTBLS14421 | MetaboLights
TranscriptomicsCytosolic glutamine synthetase 1;1 knockout effects on rice roots
Goal of the study is to characterize distinct function(s) of two cytosolic glutamine synthetase (GS) in rice plants. We grew rice lacking GS1;1 and GS1;2 under the ammonium sufficient condition. We harvested roots from the two mutants as well as those of the corresponding control.
ORGANISM(S): Oryza sativa Japonica Group 
2019-04-01 | E-MTAB-6303 | biostudies-arrayexpress
ProteomicsYeast glutamine tRNA synthetase doxycycline shut-off
During protein synthesis, charged tRNAs deliver amino acids to translating ribosomes, and are then re-charged by tRNA synthetases (aaRS). In humans, mutant aaRS cause a diversity of neurological disorders, but their molecular aetiologies are incompletely characterised. To understand system responses...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-02-12 | PXD017140 | Pride
Saccharomyces cerevisiae Silac Translation Trna synthetase depletion 
TranscriptomicsGene expression data from phosphinothricin (PPT) treated Medicago truncatula root nodules
Nitrogen assimilation in plants is a tightly regulated process that integrates developmental and environmental signals. The legume-rhizobial symbiosis results in the formation of a specialized organ called root nodule, where the rhizobia fixes atmospheric nitrogen into ammonia. Ammonia is assimilate...
ORGANISM(S): Medicago truncatula 
2012-05-08 | E-GEOD-34155 | biostudies-arrayexpress
ProteomicsPeroxynitrite-mediated post-translational modification of human glutamine synthetase
The aim of the project was to understand the mechanisms that underlie the oxidative inactivation of human glutamine synthetase (HsGS). For that purpose, we expressed and purified recombinant HsGS, exposed it in phosphate buffer to peroxynitrite (ONOO-) and assessed the functional and structural cons...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037583 | Pride
Peroxynitrite Glutamine synthetase Oxidative stress Protein oxidation Nitrotyrosine 
TranscriptomicsWild type vs glnPA double mutant
This microarray experiment is part of a study addressing the importance of glutamine metabolism in Streptococcus pneumoniae for the virulence of this bacterium. To be able to gain more insight into the phenotype of a double mutant of glnA (TIGR 4 locus tag SP0502, encoding glutamine synthetase) and ...
ORGANISM(S): Streptococcus pneumoniae 
2010-05-26 | E-GEOD-9850 | biostudies-arrayexpress
TranscriptomicsThe gene expression response of MCF7 and MDAMB231 to glutamine deprivation
There are two major subtype of cells in breast cancer. These cancer cells response differently to glutamine deprivation, here we use one luminal type of breast cancer cell (MCF7) and one basal type of breast cancer cell (MDAMB231) to compare the gene expression differences of these two types of canc...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-26370 | biostudies-arrayexpress
MetabolomicsPlasmodium falciparum metabolomics as a result of treatment with putative acetyl-CoA synthetase inhibitors
Not available
ORGANISM(S): Plasmodium falciparum 
ST001660 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of yeast under conditions of ammonium, L-alanine or L-glutamine limitation
Response of Saccharomyces cerevisiae to Ammonium, L-alanine, or L-glutamine Limitation. The protrotophic laboratory strain CEN.PK113-7D (MAT a) was grown in laboratory fermentors with a working volume of 1 litre at dilution rate (D) of 0.20 per hour (in triplicate for each nitrogen limited condition...
ORGANISM(S): Saccharomyces cerevisiae 
2006-06-13 | E-MEXP-724 | biostudies-arrayexpress
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