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MetabolomicsPathological glutaminolysis induces mitochondrial injury via OPA1 glutamylation in renal fibrosis

The promotion of repair in proximal renal tubular epithelial cells (PTEC) or the prevention of repair failure has been suggested as a beneficial strategy for mitigating the progression of chronic kidney disease (CKD). However, effective interventions to halt CKD progression and subsequent renal f...

2025-10-15 | MTBLS13145 | MetaboLights
MetabolomicsPathological glutaminolysis induces mitochondrial injury via OPA1 glutamylation in renal fibrosis

The promotion of repair in proximal renal tubular epithelial cells (PTEC) or the prevention of repair failure has been suggested as a beneficial strategy for mitigating the progression of chronic kidney disease (CKD). However, effective interventions to halt CKD progression and subsequent renal f...

2025-10-23 | MTBLS13148 | MetaboLights
ProteomicsAnalysis of SdeA modification by SidJ
Legionella pneumophila is a pathogenic gram-negative bacterium that evades host defense pathways to establish its intracellular replicative niche1. SidE family (SidEs) effectors mediate phosphoribosyl (PR)-dependent ubiquitination of host substrates and promote bacterial infection. Legionella effect...
ORGANISM(S): Homo sapiens (Human) Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) 
2019-07-16 | PXD014362 | Pride
Glutamylation Legionella pneumophila 
ProteomicsDifferential modifications of the C-terminal tails of alpha-tubulin isoforms and their importance for kinesin-based microtubule transport in vivo
Microtubules (MTs) are built from alpha/beta-tubulin dimers and used as tracks by kinesin and dynein motors to transport a variety of cargos, such as mRNAs, proteins, and organelles, within the cell. Tubulins are subjected to several post-translational modifications (PTMs). Glutamylation is one of t...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-07-11 | PXD035270 | Pride
Alpha-tubulin glutamylation In vivo function Axonal transport Ttll5 Microtubule transport Oogenesis 
UnknownGlutamylation is a negative regulator of microtubule growth.
Not available
S-EPMC10295482 | biostudies-literature
UnknownGlutamylation of centrosomes ensures their function by recruiting microtubule nucleation factors.
Not available
S-EPMC12084555 | biostudies-literature
UnknownPoly-γ-glutamylation of biomolecules.
Not available
S-EPMC10861534 | biostudies-literature
UnknownCytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function.
Not available
S-EPMC4055263 | biostudies-literature
UnknownKLC3 regulates axonemal glutamylation via RAB11/FIP5 in polycystic kidney disease.
Not available
S-EPMC12613517 | biostudies-literature
UnknownThe Emerging Roles of Axonemal Glutamylation in Regulation of Cilia Architecture and Functions.
Not available
S-EPMC7970040 | biostudies-literature
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