Sort   by:  
 Page size 
ProteomicsArzanol Biomolecular Targets - Chemoproteomic fishing identifies arzanol as a positive modulator of brain glycogen phosphorylase
The interactome of arzanol was investigated by MS-based chemical proteomics, a pioneering technology for small molecules target discovery. Brain glycogen phosphorylase (bGP), a key regulator of glucose metabolism so far refractory to small molecule modulation, was identified as the main high-affinit...
ORGANISM(S): Homo sapiens (Human) 
2019-03-25 | PXD011170 | Pride
Arzanol Chemical proteomics Brain glycogen phosphorylase 
ProteomicsA proteomic platform unveils the brain glycogen phosphorylase as a potential metabolic target for glioblastoma multiforme
In the last few years, several efforts have been ended to identify original strategies against gli-oblastoma multiforme (GBM): this requires a more detailed investigation of the molecular mechanism of GBM so that novel targets can be identified for new possible therapeutic agents. Here, using a combi...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD034933 | Pride
3-benzodiazepin-4-one Glycogen phosphorylase Proteomics 2 Target identification Glioblastoma multiforme 
UnknownLiver Glycogen Phosphorylase Deficiency Leads to Profibrogenic Phenotype in a Murine Model of Glycogen Storage Disease Type VI.
Not available
S-EPMC6824077 | biostudies-literature
ModelsRozi2003_GlycogenPhosphorylase_Activation
The model reproduces the temporal evolution of Glycogen phosphorylase for a vale of Vm5=30 as depicted in Fig 1a of the paper. The model makes use of calcium oscillations from the Borghans model to stimulate the activation of glycogen phosphorylase. Hence, this is a simple extension of the Borghans ...
2024-09-02 | BIOMD0000000100 | BioModels
TranscriptomicsAnalysis of global changes in gene expression induced by human polynucleotide phosphorylase (hPNPaseold-35)
Human Polynucleotide Phosphorylase (hPNPaseold-35) is an evolutionarily conserved 3’?5’ exoribonuclease implicated in the regulation of numerous physiological processes like maintenance of mitochondrial homeostasis, mtRNA import and aging-associated inflammation. From an RNase perspective, little is...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-53604 | biostudies-arrayexpress
UnknownMitochondrial Redox Status Regulates Glycogen Metabolism via Glycogen Phosphorylase Activity.
Not available
S-EPMC11590902 | biostudies-literature
Genomics
Glycogen muscle phosphorylase CRISPR/Cas9 mutants sequencing
PRJNA1466787 | ENA
UnknownThe regulatory α and β subunits of phosphorylase kinase directly interact with its substrate, glycogen phosphorylase.
Not available
S-EPMC5195864 | biostudies-literature
UnknownMuscle Glycogen Phosphorylase and Its Functional Partners in Health and Disease.
Not available
S-EPMC8070155 | biostudies-literature
UnknownC-Glucopyranosyl-1,2,4-triazoles As New Potent Inhibitors of Glycogen Phosphorylase.
Not available
S-EPMC4027562 | biostudies-literature
Sort   by:  
 Page size