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UnknownDicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics.
Not available
S-EPMC4975768 | biostudies-literature
GenomicsGlyoxalase 1 Knockout Promotes Age- and Sex-dependent Obesity and Metabolic Dysfunction
Glyoxalase 1 Knockout Promotes Age- and Sex-dependent Obesity and Metabolic Dysfunction
PRJNA484131 | ENA
ProteomicsRyR2-mediated calcium leak increases glyoxalase I in the aging brain
Ryanodine receptor 2 (RyR2) mediated chronic calcium leak in the brain has been implicated in patients with late-onset Alzheimer’s disease (LOAD) and from aging macaques, but the direct downstream consequences of calcium leak remain unclear. Here, we present that RyR2 mediated chronic calcium leak l...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-25 | PXD053288 | Pride
Glyoxalase i  ryanodine receptor 2  calcium dysregulation  aging  macaque  prefrontal cortex  hippocampus  proteomics 
UnknownTrypanothione-dependent glyoxalase I in Trypanosoma cruzi.
Not available
S-EPMC1652828 | biostudies-literature
ProteomicsAluminum and salt induced protein changes in tomato overexpressing a glyoxalase I gene
In this project, seedlings of tomato (Solanum lycopersicum) ‘Money Maker’ plants overexpressing a glyoxalase I gene were treated under 20 µM Al3+ and salt (200 mM NaCl) for two weeks. The treatments were conducted in hydroponic solutions in a greenhouse at 24±2C without supplemental light. Roots ha...
ORGANISM(S): Solanum lycopersicum 
2020-04-09 | PXD009456 | Pride
Aluminum Root Methylglyoxal Salt 
TranscriptomicsGlyoxalase 1 Knockout Promotes Age- and Sex-dependent Obesity and Metabolic Dysfunction
Glyoxalase 1 (Glo1) is a critical enzyme responsible for the clearance of toxic dicarbonyls, which modify proteins to produce advanced glycation end products (AGEs). Glo1 has been recently implicated in the progression of metabolic disorders, however underlying mechanisms are poorly understood. We a...
ORGANISM(S): Mus musculus 
2018-08-03 | GSE118034 | GEO
UnknownTemporal dynamics of glyoxalase 1 in secondary neuronal injury.
Not available
S-EPMC3911945 | biostudies-literature
ProteomicsHepatic dysregulation of glyoxalase 1 in preclinical models and patients with non-alcoholic fatty liver disease
Background & Aims: Although non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, aspects of its molecular pathogenesis are unknown and clinical biomarkers for early diagnosis and accurate disease staging remain scarce. The aims of these experiments were to identify...
ORGANISM(S): Mus musculus (Mouse) 
2018-02-16 | PXD001442 | Pride
Quantitative proteomics Glyoxalase Mouse Q-tof Nlc-ms/ms Liver Itraq 
UnknownStructural variation in bacterial glyoxalase I enzymes: investigation of the metalloenzyme glyoxalase I from Clostridium acetobutylicum.
Not available
S-EPMC3207458 | biostudies-literature
UnknownStructural studies on a mitochondrial glyoxalase II.
Not available
S-EPMC1343529 | biostudies-literature
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