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ProteomicsOncogenic mutations in the Gα-protein GNA11 convey a shorter disease specific survival and are more strongly associated with loss of BAP1 and chromosomal alterations than GNAQ mutations in uveal melanoma
Mutations of the Gα-proteins GNAQ and GNA11 are found in 85-90% of uveal melanomas (UMs). We analyzed the association of GNAQ and GNA11 mutations with disease-specific survival, gene expression profiles, and cytogenetic alterations in 219 UMs. Our analysis showed a shorter disease-specific survival ...
ORGANISM(S): Homo sapiens (Human) 
2022-06-22 | PXD030217 | Pride
Bap1 Gna11 Gnaq Metastasis risk Asap1 
UnknownMutations in GNA11 in uveal melanoma.
Not available
S-EPMC3107972 | biostudies-literature
GenomicsMus musculus
Expression profiles of genetically engineered mouse model tumors (GNA11 Q209L and GNA11 Q209L Bap1 KO)
PRJNA381017 | ENA
UnknownGNA11 Variants Identified in Patients with Hypercalcemia or Hypocalcemia.
Not available
S-EPMC10947407 | biostudies-literature
UnknownUveal Melanocytoma without GNAQ/GNA11 Mutations.
Not available
S-EPMC12705124 | biostudies-literature
TranscriptomicsIn uveal melanoma Gα-protein GNA11 mutations convey a shorter disease-specific survival and are more strongly associated with loss of BAP1 and chromosomal alterations than Gα-protein GNAQ mutations
Mutations in the Gα-genes GNAQ and GNA11 are found in 85-90% of uveal melanomas (UMs). We analyzed the association between GNAQ and GNA11 mutations with disease-specific survival, gene expression profiles, and cytogenetic alterations in 219 UMs. Our analysis showed a shorter disease-specific surviva...
ORGANISM(S): Homo sapiens 
2023-02-27 | GSE197656 | GEO
UnknownMutation spectrum in GNAQ and GNA11 in Chinese uveal melanoma.
Not available
S-EPMC8985776 | biostudies-literature
UnknownSomatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma.
Not available
S-EPMC4833432 | biostudies-literature
UnknownSomatic GNA11/GNAQ variants in a cohort of Chinese children with phakomatosis pigmentovascularis.
Not available
S-EPMC11193378 | biostudies-literature
UnknownCombined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations.
Not available
S-EPMC4524511 | biostudies-literature
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