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ProteomicsMITF deficiency accelerates GNAQ-driven uveal melanoma
Cutaneous melanoma (CM) and uveal melanoma (UM) both originate from the melanocytic lineage but are primarily driven by distinct oncogenic drivers, BRAF/NRAS or GNAQ/GNA11 respectively. The melanocytic master transcriptional regulator, MITF, is essential for both CM development and maintenance, but ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2023-03-11 | PXD030527 | Pride
Uveal melanoma Phospho Mitf Zebrafish 
ProteomicsOncogenic mutations in the Gα-protein GNA11 convey a shorter disease specific survival and are more strongly associated with loss of BAP1 and chromosomal alterations than GNAQ mutations in uveal melanoma
Mutations of the Gα-proteins GNAQ and GNA11 are found in 85-90% of uveal melanomas (UMs). We analyzed the association of GNAQ and GNA11 mutations with disease-specific survival, gene expression profiles, and cytogenetic alterations in 219 UMs. Our analysis showed a shorter disease-specific survival ...
ORGANISM(S): Homo sapiens (Human) 
2022-06-22 | PXD030217 | Pride
Bap1 Gna11 Gnaq Metastasis risk Asap1 
GenomicsTranscriptional changes in GNAQ R183Q mouse back skin
Transcriptional changes in GNAQ R183Q mouse back skin
PRJNA1439910 | ENA
GenomicsMITF deficiency accelerates GNAQ-driven uveal melanoma
MITF deficiency accelerates GNAQ-driven uveal melanoma
PRJNA788496 | ENA
GenomicsGNAQ deep sequencing in skin biopsies from individuals with Sturge Weber syndrome
Deep sequencing of GNAQ in skin biopsies
PRJEB85882 | ENA
GenomicsRNA-sequencing of Endothelial Cell Lines Expressing GNAQ WT or Mutant Q209L
RNA-sequencing of Endothelial Cell Lines Expressing GNAQ WT or Mutant Q209L
PRJNA893224 | ENA
TranscriptomicsExpression data from human melanoma cell lines with or without GNAQ/11 mutation
We used microarray to compare global gene expression profiles between 5 GNAQ/11 mutant uveal melanoma cell lines (GNAQ mutant: 92-1, omm1.3, mel270; GNA11 mutant: omm-gn11 and upmd-1) and 5 GNAQ/11 wild type melanoma cell lines(sk-mel-2, mm415, mm485, sk-mel-5 and mum2c). Uveal melanoma is the most ...
ORGANISM(S): Homo sapiens 
2017-07-01 | GSE93666 | GEO
Genomics
GNAQ
PRJNA1240797 | ENA
Genomics
GNAQ
PRJNA1240860 | ENA
TranscriptomicsTranscriptional changes in GNAQ R183Q mouse back skin
We used RNA-Seq to search for potential downstream effectors of GNAQ R183Q during the developent of vascular phenotypes in the mouse back skin.
ORGANISM(S): Mus musculus 
2026-03-30 | GSE325430 | GEO
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