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GenomicsBRG1 recruitment by transcription factors MITF and SOX10 defines a specific configuration of regulatory elements in the melanocyte lineage (ChIP-seq)
Microphthalmia-associated transcription factor (MITF) is the master regulator of the melanocyte lineage. By tandem affinity purification and mass spectrometry, we present a comprehensive characterisation of the MITF interactome comprising multiple novel cofactors involved in transcription, DNA repli...
ORGANISM(S): Homo sapiens 
2015-04-02 | E-GEOD-61965 | biostudies-arrayexpress
GenomicsMITF ChIP-seq in primary melanocyte and melanoma as a function of oncogenic BRAF
Thousands of enhancers are characterized in the human genome, yet few have been shown important in cancer. Inhibiting oncokinases, such as EGFR, ALK, HER2, and BRAF, is a mainstay of current cancer therapy but is hindered by innate drug resistance mediated by upregulation of the HGF receptor, MET. T...
ORGANISM(S): Homo sapiens 
2014-01-14 | E-GEOD-50681 | biostudies-arrayexpress
ProteomicsO-GlcNAcylation promotes Palbociclib resistance in breast cancer by regulating MITF nuclear translocation
Cyclin-dependent kinases 4 and 6 (CDK4/6) are essential drivers of the cell cycle and are also critical for the initiation and progression of diverse malignancies. Pharmacological inhibitors targeting CDK4/6 have demonstrated significant activity against various tumor types such as breast cancer. Ho...
ORGANISM(S): Homo sapiens (Human) 
2024-05-30 | PXD042838 | Pride
Mitf Palbociclib O-glcnac 
TranscriptomicsComparing the effects of MITF on transcriptional regulation to the TEN1-ICD
We identified histidine triad nucleotide binding protein 1 (HINT1) as a human teneurin-1 ICD interaction partner in a yeast-2 hybrid screen. This interaction was confirmed in human cells, where HINT1 is known to inhibit the transcription of target genes by directly binding to transcription factors a...
ORGANISM(S): Homo sapiens 
2015-02-04 | E-GEOD-61705 | biostudies-arrayexpress
TranscriptomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
We identified a novel germline mutation of the microphthalmia-associated transcription factor (MITF - E318K). This mutation was found to be present in numerous melanoma families, as well as the general population, where its association with melanoma has a significant effect. We determined the effe...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-31269 | biostudies-arrayexpress
TranscriptomicsBRG1 recruitment by transcription factors MITF and SOX10 defines a specific configuration of regulatory elements in the melanocyte lineage (RNA-seq)
Microphthalmia-associated transcription factor (MITF) is the master regulator of the melanocyte lineage. By tandem affinity purification and mass spectrometry, we present a comprehensive characterisation of the MITF interactome comprising multiple novel cofactors involved in transcription, DNA repli...
ORGANISM(S): Homo sapiens 
2015-04-02 | E-GEOD-61966 | biostudies-arrayexpress
TranscriptomicsOncogenic BRAF regulates oxidative metabolism via PGC1alpha and MITF
We evaluated two matched human cell lines derived from primary melanocytes, termed pmel+BRAF(V600E) and pmel+BRAF(V600E)+MITF. These cells are therefore isogenic with the exception of the expression of MITF. Gene Set Enrichment Analysis of microarray data identified a highly significant induction of...
ORGANISM(S): Homo sapiens 
2013-03-07 | E-GEOD-38007 | biostudies-arrayexpress
ProteomicsMITF deficiency accelerates GNAQ-driven uveal melanoma
Cutaneous melanoma (CM) and uveal melanoma (UM) both originate from the melanocytic lineage but are primarily driven by distinct oncogenic drivers, BRAF/NRAS or GNAQ/GNA11 respectively. The melanocytic master transcriptional regulator, MITF, is essential for both CM development and maintenance, but ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2023-03-11 | PXD030527 | Pride
Uveal melanoma Phospho Mitf Zebrafish 
ProteomicsO-GlcNAcylation promotes Palbociclib resistance in breast cancer by regulating MITF nuclear translocation
Cyclin-dependent kinases 4 and 6 (CDK4/6) are essential drivers of the cell cycle and are also critical for the initiation and progression of diverse malignancies. Pharmacological inhibitors targeting CDK4/6 have demonstrated significant activity against various tumor types such as breast cancer. Ho...
ORGANISM(S): Homo sapiens (Human) 
2024-05-30 | PXD042763 | Pride
O-glcnacylation Mitf Palbociclib 
ProteomicsBRAF/MAPK and GSK3 signaling converges to control MITF nuclear export
The close integration of the MAPK, PI3K, and WNT signaling pathways underpins much of development and is deregulatedin cancer. In principle, combinatorial posttranslational modification of key lineage specific transcription factors would be an effective mean stointegrate critical signaling events. U...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD010782 | Pride
Mitf|melanoma|mapk|nuclear export|gsk3 
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