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TranscriptomicsUDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) is an inducer of apoptotic processes in Capan-1 pancreatic carcinoma cells: GNE silencing
Early invasive growth and metastasis are features of pancreatic cancer that rely on resistance to anoikis, an apoptosis program activated upon loss of adequate matrix anchorage. Re-expression of the tumor suppressor p16 reversed anoikis resistance of pancreatic cancer cells. This conversion to an an...
ORGANISM(S): Homo sapiens 
2010-08-01 | E-GEOD-22336 | biostudies-arrayexpress
ProteomicsIn vivo and in vitro Genome Editing to explore GNE functions
GNE myopathy is an adult onset neuromuscular disorder characterized by slowly progressive distal and proximal muscle weakness, caused by missense recessive mutations in the GNE gene. Although the encoded bifunctional enzyme is well known as the limiting factor in the biosynthesis of sialic acid, no...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD033985 | Pride
Phosphoproteomics Gne Myopathy Crispr/cas9 
TranscriptomicsInduction of apoptotic processes in Capan-1 pancreatic carcinoma cells by restoration of p16INK4a expression
Early invasive growth and metastasis are features of pancreatic cancer that rely on resistance to anoikis, an apoptosis program activated upon loss of adequate matrix anchorage. Re-expression of the tumor suppressor p16 reversed anoikis resistance of pancreatic cancer cells. This conversion to an an...
ORGANISM(S): Homo sapiens 
2010-08-01 | E-GEOD-22334 | biostudies-arrayexpress
GenomicsEffect of depletion of the gne gene in Zebrafish
Effect of depletion of the gne gene in Zebrafish
PRJNA856288 | ENA
UnknownMutation update for GNE gene variants associated with GNE myopathy.
Not available
S-EPMC4172345 | biostudies-literature
GenomicsEffect of depletion of the Gne gene in Sol8 murine muscle cells
Effect of depletion of the Gne gene in Sol8 murine muscle cells
PRJNA834085 | ENA
GenomicsATAC-seq of H226 cells treated with TEAD inhibitor GNE-7883
ATAC-seq of H226 cells treated with TEAD inhibitor GNE-7883
PRJNA952669 | ENA
TranscriptomicsEffect of depletion of the gne gene in Zebrafish
GNE Myopathy is a rare, recessively inherited neuromuscular worldwide disorder, caused by a spectrum of bi-allelic mutations in the human GNE gene. GNE encodes a bi-functional enzyme responsible for the rate-limiting step of sialic acid biosynthesis pathway. However, the process in which GNE mutatio...
ORGANISM(S): Danio rerio 
2022-10-26 | GSE207593 | GEO
GenomicsRNA-seq of MCF-7 cells treated with GDC-9545 and GNE-858
RNA-seq of MCF-7 cells treated with GDC-9545 and GNE-858
PRJNA1032619 | ENA
GenomicsATAC-seq of MCF-7 cells treated with GDC-9545 and GNE-858
ATAC-seq of MCF-7 cells treated with GDC-9545 and GNE-858
PRJNA1032604 | ENA
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