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ProteomicsIdentification of 60S pre-rRNA binding sites of human GNL3L GTPase
We reveal that the GNL3 paralogue GTPase, GNL3L, associates with pre-ribosomes. We map RNA contact sites on GNL3L as well as GNL3L binding sites on pre-rRNAs. Lack of GNL3L impairs synthesis of the 60S rRNAs and expression of GTPase inactive GNL3L causes defects in early steps of pre-rRNA processing...
ORGANISM(S): Homo sapiens (Human) 
2026-03-05 | PXD067606 | Pride
Human Gtpase Gnl3l 60s rrna Rna-protein crosslinking 
UnknownGNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest.
Not available
S-EPMC3072457 | biostudies-literature
UnknownGNL3L Is a Nucleo-Cytoplasmic Shuttling Protein: Role in Cell Cycle Regulation.
Not available
S-EPMC4537249 | biostudies-literature
UnknownGNL3L inhibits activity of estrogen-related receptor gamma by competing for coactivator binding.
Not available
S-EPMC2975966 | biostudies-literature
ProteomicsDistinct steps of nuclear maturation of human pre-60S complexes require the activity of GTPases, including GNL3L
Production of the eukaryotic ribosomal subunits (40S and 60S) is a highly dynamic process in which numerous assembly factors coordinate structural rearrangements of pre-ribosomal complexes to achieve their mature, functional architectures. Across the domains of life, GTPases leverage their functions...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD068314 | Pride
Ribosome biogenesis Gtpase Ribosomal protein Gtpbp4 Gnl2 Pre-rrna processing Gnl3 Translation 
UnknownChemoresistance-Associated Silencing of miR-4454 Promotes Colorectal Cancer Aggression through the GNL3L and NF-κB Pathway.
Not available
S-EPMC7281507 | biostudies-literature
UnknownKnockdown of GNL3L Alleviates the Progression of COPD Through Inhibiting the ATM/p53 Pathway.
Not available
S-EPMC10664632 | biostudies-literature
UnknownThe homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA.
Not available
S-EPMC1345682 | biostudies-literature
OtherThe roles of GTPases in biogenesis of the large ribosomal subunit
Ribosomes are ribonucleoprotein complexes responsible for protein synthesis, and their biogenesis is a complex, highly orchestrated process. Formation of the ribosomal subunits is coordinated by trans-acting ribosome biogenesis factors (RBFs) that mediate ribosomal RNA (rRNA) modification, folding a...
ORGANISM(S): Homo sapiens 
2026-03-11 | GSE302147 | GEO
UnknownNucleolar trafficking of nucleostemin family proteins: common versus protein-specific mechanisms.
Not available
S-EPMC2169394 | biostudies-literature
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