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MetabolomicsThe GNMT N-terminus Couples Folate Feedback to Methyl-donor Homeostasis
Maintenance of S-adenosylmethionine (SAM) homeostasis is essential for methylation of biomolecules, nucleotide and polyamine synthesis, and redox balance. While all methyltransferases consume SAM, only a subset of highly tissue specific methyltransferases regulates methylation potential. Among them,...
2026-08-18 | MTBLS15161 | MetaboLights
TranscriptomicsExpression data from GNMT knockout mice
We report that 7 of 7 female Gnmt-/- mice developed hepatocellular carcinoma (HCC), the most common form of liver cancer, at the mean age of 16.1 months. In contrast, only one-third (2/6) of male Gnmt-/- mice had HCC, the remaining had either premature death or liver necrosis. Microarray analysis sh...
ORGANISM(S): Mus musculus 
2008-12-01 | E-GEOD-9809 | biostudies-arrayexpress
TranscriptomicsExpression data from AFB1-treated GNMT knockout mice
We report that liver nodules from 5/8 (62.5%) male and 4/5 (80%) female Gnmt-/- mice were diagnosed as having HCC. Microarray analysis showed that genes involved in the following pathways were deregulated in different stages of tumorigenesis: Methylation, metabolism, signal transduction, cell prolif...
ORGANISM(S): Mus musculus 
2009-10-02 | E-GEOD-18218 | biostudies-arrayexpress
TranscriptomicsExpression data from GNMT knockout mice in Hepatocytes and OKER cell lines
Hepatocellular carcinoma (HCC) is the first cause of death in cirrhotic patients. Liver cirrhosis at a high risk of HCC has abnormal S-Adenosylmethionine (SAMe) levels. Catabolism of SAMe is mainly mediated by Glycine N-methyltransferase (GNMT), Lack in GNMT expression leads to epigenetic regulation...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-34838 | biostudies-arrayexpress
TranscriptomicsExpression data from GNMT knockout mice cerebral cortex
We report that Gnmt-/- mice have abnormal behavior including spontaneous locomotion activity, PPI, TST and FST. Microarray analysis showed that genes expression profiles in male Gnmt -/- mice Keywords: Gnmt knockout Cerebral cortex tissues from wild-type or Gnmt knockout mice were used for RNA ext...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-23937 | biostudies-arrayexpress
ProteomicsDynamic N-terminal regulation couples GNMT folate feedback to methyl-donor homeostasis
One carbon metabolism supports essential cellular functions, including biomolecule methylation, nucleotide and polyamine synthesis, and redox homeostasis. These processes depend on maintenance of S-adeno-sylmethionine (SAM) homeostasis. Although all methyltransferases consume SAM, only a subset appe...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-18 | PXD078525 | Pride
Sam Folate One carbon metabolism Methylation Gnmt Methionine 
GenomicsThe GNMT N-terminus Couples Folate Feedback to Methyl-donor Homeostasis
The GNMT N-terminus Couples Folate Feedback to Methyl-donor Homeostasis
PRJNA1472117 | ENA
TranscriptomicsExpression data from GNMT knockout mice cerebral cortex
We report that Gnmt-/- mice have abnormal behavior including spontaneous locomotion activity, PPI, TST and FST. Microarray analysis showed that genes expression profiles in male Gnmt -/- mice Keywords: Gnmt knockout
ORGANISM(S): Mus musculus 
2011-09-01 | GSE23937 | GEO
TranscriptomicsExpression data from GNMT knockout mice
We report that 7 of 7 female Gnmt-/- mice developed hepatocellular carcinoma (HCC), the most common form of liver cancer, at the mean age of 16.1 months. In contrast, only one-third (2/6) of male Gnmt-/- mice had HCC, the remaining had either premature death or liver necrosis. Microarray analysis sh...
ORGANISM(S): Mus musculus 
2008-12-01 | GSE9809 | GEO
GenomicsEffect of Gnmt overexpression on histone methylation abundance in Drosophila melanogaster photoreceptor cells
Effect of Gnmt overexpression on histone methylation abundance in Drosophila melanogaster photoreceptor cells
PRJNA1305311 | ENA
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