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TranscriptomicsTranscription profiling of mouse allergen-induced goblet cells
High numbers of goblet cells in airways contribute to the mucus obstruction characteristic of asthmatic airways. Allergen challenged mice exhibit robust expression of goblet cells within airway surface epithelium. This study looks at the temporal analysis of IL-13 exposed murine airways to elucida...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-481 | biostudies-arrayexpress
TranscriptomicsComparison of Cancer-Associated Genetic Abnormalities in Columnar-Lined Esophagus with and without Goblet Cells
The requirement of goblet cells (intestinal metaplasia; IM) to define BarrettM-bM-^@M-^Ys esophagus (BE) remains controversial as some studies have shown that the risk of progression to esophageal adenocarcinoma (EAC) is similar for non-goblet cell metaplasia (NGM) and IM. IM harbors genomic aberrat...
ORGANISM(S): Homo sapiens 
2012-12-15 | E-GEOD-40769 | biostudies-arrayexpress
ProteomicsTrans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation
A key feature in intestinal immunity is the dynamic intestinal barrier, which separates the host from resident and pathogenic microbiota through a mucus gel impregnated with antimicrobial peptides. The mechanisms underlying the maintenance and function of this intestinal barrier are not completely ...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD038895 | Pride
Glycosylation N-ethyl-n-nitrosourea (enu) Inflammatory bowel disease (ibd) Goblet cel Paneth cell Dextran sodium sulfate (dss) 
TranscriptomicsTranscription profiling of mouse cystic fibrosis model Cftr knockouts ileum were analysed to investigate intestinal phenotypes
Cystic fibrosis transmembrane conductance regulator (Cftr) knockout mice present the clinical features of low body weight and intestinal disease permitting an assessment of the interrelatedness of these phenotypes in a controlled environment. To identify intestinal alterations which affect body wei...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5715 | biostudies-arrayexpress
UnknownDecreased nutrient digestibility due to viscosity is independent of the amount of dietary fibre fed to growing pigs.
Not available
S-EPMC8756099 | biostudies-literature
TranscriptomicsTranscription profiling of jejunums from wild type and Klf9-/- mice to investigate the involvement of Klf9 in small intestine crypt-villus cell renewal and lineage determination.
Kruppel-like factor 9 (Klf9), a zinc-finger transcription factor, is implicated in the control of cell proliferation, cell differentiation and cell fate in brain and uterus. Using Klf9 null mutant mice, we have investigated the involvement of Klf9 in small intestine crypt-villus cell renewal and li...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6443 | biostudies-arrayexpress
TranscriptomicsscRNAseq of small intestine-derived lamina propria CD45+ cells from untreated wild type (WT), untreated intestinal epithelial specific LSD1 knockout (cKO), antibiotic-treated WT mice and antibiotic-treated cKO mice
Mice with an intestinal epithelial specific knockout of LSD1 have changes in the intestinal epithelium including loss of Paneth and Goblet cells along with a general status of epithelial immaturity. To assess the influence of these epithelial specific changes on the mucosal immune system we performe...
ORGANISM(S): Mus musculus 
2023-08-02 | E-MTAB-10492 | biostudies-arrayexpress
TranscriptomicsTranscription profilign of pig corneal and conjunctival keratinocyte clones
Integrity of the cornea, the most anterior part of the eye is indispensable for vision. 45 million individuals are bilaterally blind and another 135 millions have severely impaired vision in both eyes because of loss of corneal transparency; treatments range from local medications to corneal transpl...
ORGANISM(S): Sus scrofa 
2008-10-25 | E-GEOD-12604 | biostudies-arrayexpress
TranscriptomicsHuman primary airway epithelial cell cultures infected with human- and swine-origin influenza viruses
Cultures of primary human airway epithelial cells (HAE cells) were exposed to an MDCK equivalent MOI of 0.01 of several swine- and human-origin influenza viruses and RNA was extracted at the 12, 16, and 24 hours post infection. 64 samples consiting of 5 influenza strains, 3 time points and 2 or 3 re...
ORGANISM(S): Homo sapiens 
2012-10-11 | E-GEOD-41475 | biostudies-arrayexpress
TranscriptomicsATAC-sequencing mice small intestinal epithelium with intestinal epithelium specific LSD1 knock out compared to wild type
To study the epigenetic regulation of intestinal epithelium we focus on the role of chromatin modulators. Lysine-specific histone demethylase 1a (KDM1A, LSD1) is one of the enzymes that can erase the H3K4me1/2 mark. To assess the role of LSD1 in intestinal epithelium we studied wild type (WT) (Villi...
ORGANISM(S): Mus musculus 
2021-03-23 | E-MTAB-8718 | biostudies-arrayexpress
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