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TranscriptomicsTranscript analyses of cisplatin and Sky1 effects in Saccharomyces cerevisiae
Sky1 is a Saccharomyces cerevisiae rich serine-arginine (SR) protein-specific kinase and its enzymatic activity is essential in the cytotoxicity caused by cisplatin, although the molecular mechanisms supporting this function are not understood. We present a transcriptome analysis discriminating betw...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-01 | E-GEOD-41094 | biostudies-arrayexpress
UnknownFirst-in-Human Phase I Study of the Tamoxifen Metabolite Z-Endoxifen in Women With Endocrine-Refractory Metastatic Breast Cancer.
Not available
S-EPMC5648176 | biostudies-literature
TranscriptomicsToxic effects of dietary methylmercury (MeHg) on juvenile rainbow trout
Juvenile rainbow trout were fed Biodiet starter (4% body weight per day) with MeHg added at 0, 0.5, 5 and 50 ppm for six weeks. Atomic absorption spectrometry was applied to measure the level of MeHg in the whole fish body. Trout at six weeks were sampled from each group for gene expression analysis...
ORGANISM(S): Oncorhynchus mykiss 
2013-06-01 | E-GEOD-32429 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of blastomeres from 2- to 32-cell stage mouse embryos
Transcriptomes were determined for all blastomeres of 28 embryos at the 2- (n=8), 4- (n=16) and 8-cell (n=4) stages, and for individual cells taken from 16- (n=6) and 32- (n=6) cell stage embryos. We also carefully monitored the 2- to 4-cell divisions noting whether the cleavage plane was meridional...
ORGANISM(S): Mus musculus 
2016-03-23 | E-MTAB-3321 | biostudies-arrayexpress
ProteomicsEndoxifen Downregulates AKT Phosphorylation Through Protein Kinase C Beta 1 in ER+/HER2- Breast Cancer
In phase I/II clinical trials, Z-endoxifen demonstrated substantial oral bioavailability and promising antitumor activity in endocrine-refractory estrogen-receptor positive breast cancer (ER+ BC) and other solid tumors, with plasma concentrations reportedly as high as 5 ï�M. Therefore, we explored t...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD035007 | Pride
Breast cancer Endoxifen Mass spectrometry Pkc-beta-1 Akt Apoptosis Phosphoproteome 
UnknownNew potently bioactive alkaloids from Crinum erubescens.
Not available
S-EPMC5065785 | biostudies-literature
UnknownThymine DNA glycosylase is an RNA-binding protein with high selectivity for G-rich sequences.
Not available
S-EPMC10124917 | biostudies-literature
TranscriptomicsPRAME induced inhibition of retinoic acid receptor signaling-mediated differentiation - a possible target for ATRA response in AML without t(15;17)
Purpose: In acute myeloid leukemia (AML) without retinoic acid receptor (RAR) rearrangement the effect of all-trans retinoic acid (ATRA) is still poorly understood despite an association of NPM1 mutation and ATRA response. Recently, PRAME (preferentially expressed antigen in melanoma) has been shown...
ORGANISM(S): Homo sapiens 
2013-03-10 | E-GEOD-43258 | biostudies-arrayexpress
UnknownInvestigation of a severe SARS-CoV-2 outbreak in a long-term care home early in the pandemic.
Not available
S-EPMC8158000 | biostudies-literature
UnknownAntiproliferative Homoisoflavonoids and Bufatrienolides from Urginea depressa.
Not available
S-EPMC3736822 | biostudies-literature
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