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TranscriptomicsInvestigating the impact of heterologous expression of the Micrococcus luteus FabH on global transcription in Escherichia coli
Investigation of whole genome gene expression level changes in a E. coli fatty acid overproducing strain with or without heterologous expression of the M. luteus FabH. The strain expressing M. luteus FabH produces more methyl ketones. This study will be further described in Goh, E.B., E.E.K. Baido...
ORGANISM(S): Escherichia coli K-12 
2012-01-26 | E-GEOD-32561 | biostudies-arrayexpress
TranscriptomicsPachytene piRNAs target endogenous mRNAs for silencing during meiosis
During embryonic germ cell development in mice, transposon-enriched, piwi-interacting RNAs (piRNAs) guide MILI and MIWI2 to direct silencing of potentially active mobile element families. In contrast, we know much less about the function of the highly abundant and extremely diverse class of piRNAs, ...
ORGANISM(S): Mus musculus 
2015-05-22 | E-GEOD-64138 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression of livers of wild type and IL-4/IL-13-/- mice after carbon tetrachloride-induced injury
Global analysis of differentially expressed genes of livers of wild type and IL-4/IL-13-/- two days after carbon tetrachloride treatment. Total RNA obtained from isolated livers from vehicle and carbon tetrachloride administered wild type and IL-4/IL-13-/- mice.
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-45002 | biostudies-arrayexpress
TranscriptomicsDomestication and growth hormone transgenesis cause similar changes in gene expression profiles in coho salmon
By directly comparing gene expression in wild type, domestic, and GH transgenic strains of salmon, we have found that domestication and GH transgenesis are modifying similar genetic pathways. Genes in many different physiological pathways show modified expression in domestic and GH transgenic strain...
ORGANISM(S): Oncorhynchus kisutch 
2009-03-08 | E-GEOD-13846 | biostudies-arrayexpress
UnknownAngiotensin receptor blockers and risk of dementia: cohort study in UK Clinical Practice Research Datalink.
Not available
S-EPMC4309639 | biostudies-literature
UnknownMetabolomics and 16S rRNA sequencing of human colorectal cancers and adjacent mucosa.
Not available
S-EPMC6303059 | biostudies-literature
GenomicsDNAseq data from human ovarian carcinoma cell lines subjected to shRNA TRC1.0 library
The hallmark of human cancer is heterogeneity, mirroring the complexity of genetic and epigenetic alterations acquired during oncogenesis. We extracted DNA of 14 cultured human ovarian carcinoma cell lines subjected to pooled shRNA screen using TRC 1.0 library, and performed DNAseq. 14 ovarian carc...
ORGANISM(S): Homo sapiens 
2013-05-21 | E-GEOD-45420 | biostudies-arrayexpress
TranscriptomicsEpigenetic and transcriptional landscapes of Dnmt3a-deficient olfactory sensory neurons
During differentiation, neurons experience a reorganization of DNA modification patterns within their genomes. However, the mechanisms underlying this developmental patterning and its role in defining the neurona­­l state are currently unclear. Here, we find that the d­­e novo DNA methyltransfer...
ORGANISM(S): Mus musculus 
2014-11-05 | E-GEOD-52464 | biostudies-arrayexpress
UnknownPredictors of advanced fibrosis in elderly patients with biopsy-confirmed nonalcoholic fatty liver disease: the GOASIA study.
Not available
S-EPMC7137333 | biostudies-literature
TranscriptomicsMEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma (SCC)
Genomic analyses of SCC have yet to yield significant strategies against pathway activation to improve treatment. Platinum-based chemotherapy remains the mainstay of treatment for SCC of different histotypes either as a single agent or alongside other chemotherapeutic drugs or radiotherapy; however,...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-66549 | biostudies-arrayexpress
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