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ProteomicsFungal extract screening reveals malformin C to preferentially kill glioblastoma cells via concerted induction of proteotoxic stress and autophagic flux blockade
Azide-labelled malformin C or DMSO was incubated with protein lysate from patient derived glioblastoma stem-like cells (NCH421k), and a pulldown of the compound with Dibenzocyclooctyne (DBCO) agarose was performed in order to identify interacting proteins.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046258 | Pride
Target deconvolution Glioblastoma Stem cells 
ProteomicsIntegration of Proteomics, Phosphoproteomics and Loss-of-function Screen Identifies WEE1 Inhibition as a Combination Therapy with Dasatinib against Proneural Glioblastoma.
Background: Glioblastoma (GB) is the most common primary malignancy of the central nervous system. It can be classified into proneural (PN), mesenchymal (MES) and classical (CL) based on transcriptomics. Due to increased resistance against targeted therapies, such as the PN subtype and dasatinib, id...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD039264 | Pride
Wee1 Dasatinib Glioblastoma Silac 
ProteomicsProteomic profiling of glioblastoma stem cells and their small extracellular vesicles
The heterogeneous nature of glioblastoma stem-like cells (GSCs) creates hurdles in developing effective therapies against glioblastoma, making it extremely difficult to eradicate. In this part of the project, we investigated the potential role of GSCs-derived small extracellular vesicles (sEVs) in g...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD036359 | Pride
Glioblastoma Glioblastoma stem cells Exosomes Tumor heterogeneity Proteomics Small extracellular vesicles 
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